156136-54-8

Basic information

• Product Name: 2H-Indol-2-one, 1,3-dihydro-1-methyl-5-(trifluoromethyl)-
• Synonyms: 1-Methyl-5-trifluoromethyl-1,3-dihydro-indol-2-one;1-methyl-5-(trifluoromethyl)oxindole;5-trifluoromethyl-1-methyloxindole
• CAS NO: 156136-54-8
• Molecular Formula: C10H8F3NO
• Molecular Weight: 215.17200
• Mol File: 156136-54-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 127.5 - 129 °C (hexane)
• Boiling Point: 339.6±42.0 °C(Predicted)
• Density: 1.348±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2H-Indol-2-one, 1,3-dihydro-1-methyl-5-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Indol-2-one, 1,3-dihydro-1-methyl-5-(trifluoromethyl)-(156136-54-8)
• EPA Substance Registry System: 2H-Indol-2-one, 1,3-dihydro-1-methyl-5-(trifluoromethyl)-(156136-54-8)

Safety Data

• Hazardous Substances Data: 156136-54-8(Hazardous Substances Data)

Upstream product

• 71293-62-4 5-trifluoromethyl-2-indolinone 
• 77-78-1 dimethyl sulfate 
• 56-23-5 tetrachloromethane 
• 61-70-1 N-methyl-2-indolinone 
• 175135-49-6 N-(2-bromo-4-(trifluoromethyl)phenyl)acetamide 
• 57946-63-1 4-amino-3-bromobenzotrifluoride 
• 59-48-3 2-oxoindole 

Downstream Products

• 1027270-37-6 1-Methyl-2-thioxo-5-trifluoromethyl-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide 
• 156136-69-5 1-methyl-5-(trifluoromethyl)-2-indolinethione 

Relevant articles and documents

Regioselective electrophilic trifluoromethylation of indolines, oxindoles and indoles in superacid

Treatment of indolines and N-acylindoles with HF/SbF5/CCl 4 yields 6-trifluoro derivatives (indole numbering) whereas indoles and oxindoles give the 5-trifluoro derivatives in good yield.

2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES

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Oxindoles as sleep-inducers

Sleep inducers of the formula: STR1 wherein R is hydrogen or halo of atomic weight of from 18 to 36, R' is hydrogen, halo or CF3 and R° is hydrogen or lower alkyl. Preparation by cyclizing a 2-nitro-phenylacetic acid is also disclosed.