156143-80-5

Upstream product

• 619-66-9 4-Carboxybenzaldehyde 
• 124-38-9 carbon dioxide 
• 1291065-84-3 C₂₆H₄₅NO₄Sn 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 2109874-13-5 4-(Amino-carboxy-methyl)-benzoic acid; hydrochloride 
• 71817-33-9 4-(Amino-cyano-methyl)-benzoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 156143-83-8 C₂₈H₃₆N₂O₈S₂ 
• 156143-82-7 4-(2-Acetylsulfanyl-1-tert-butoxycarbonylamino-ethyl)-benzoic acid methyl ester 
• 156143-81-6 4-(1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of arylglycine and mandelic acid derivatives through carboxylations of α-amido and α-acetoxy stannanes with carbon dioxide

Incorporation reactions of carbon dioxide (CO2) with N-Boc-α-amido and α-acetoxy stannanes were developed using CsF as a mild tin activator. Monoprotected α-amido stannanes could be used, and the corresponding arylglycine derivatives were obtained in moderate-to-high yields under 1 MPa (10 atm) of CO2 pressure. α-Acetoxy stannanes also underwent carboxylation to afford mandelic acid derivatives in excellent yields under ambient CO2 pressure. Both transformations enabled the synthesis of α-tertiary and α-quaternary carboxylic acid derivatives. In addition, the chirality of (S)-N-tert-butylsulfonyl-α- amido stannanes was transferred with up to 90% inversion of configuration at 100 °C.

Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors

Aminopeptidase A (APA) and aminopeptidase N (APN) are two metallopeptidases which have been suggested to be involved in the enzymatic cascade of the renin-angiotensin system. APA liberates angotensin III from angiotensin II by releasing the N-terminal asp