156181-20-3Relevant articles and documents
Regio- And Stereoselective Hydroiodination of Internal Alkynes with Ex Situ-Generated HI
Nozawa-Kumada, Kanako,Noguchi, Koto,Akada, Tomoya,Shigeno, Masanori,Kondo, Yoshinori
supporting information, p. 6659 - 6663 (2021/09/08)
Herein, we report an efficient and practical hydroiodination of internal alkynes using HI generated ex situ from the readily available triethylsilane and I2. This system offers high regio- and stereoselectivity to afford (E)-vinyl iodides in good yields under mild conditions. Furthermore, the hydroiodination reaction shows high functional group tolerance toward alkyl, methoxy, halogen, trifluoromethyl, cyano, ester, halomethyl, acid-sensitive silyl ether, and acetal moieties.