1562-34-1

Basic information

• Product Name: PHENYL VINYLSULFONATE
• Synonyms: PHENYL VINYLSULFONATE;PHENYL ETHYLENESULFONATE;VINYLSULFONIC ACID PHENYL ESTER;Phenyl ethylenesulfonate, Vinylsulfonic acid phenyl ester;Ethene-1-sulfonic acid phenyl ester;Ethenesulfonic acid phenyl ester;Phenyl ethenesulfonate;Phenyl vinylsulfonate 95%
• CAS NO: 1562-34-1
• Molecular Formula: C₈H₈O₃S
• Molecular Weight: 184.21
• Mol File: 1562-34-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 38-42 °C(lit.)
• Boiling Point: 44-46 °C2 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.3761 (rough estimate)
• Vapor Pressure: 0.559mmHg at 25°C
• Refractive Index: 1.5151 (estimate)
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• Stability: Light Sensitive
• BRN: 2044718
• CAS DataBase Reference: PHENYL VINYLSULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYL VINYLSULFONATE(1562-34-1)
• EPA Substance Registry System: PHENYL VINYLSULFONATE(1562-34-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• RIDADR: 1759
• WGK Germany: 3
• F: 8
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 1562-34-1(Hazardous Substances Data)

Usage

General Description

Phenyl vinylsulfonate is an ester. Palladium complex derived from a tetraphosphine-catalyzed Heck vinylation of phenyl vinylsulfonate was reported. Phenyl vinyl sulfonate reacts with various alkyl furan derivatives to yield the corresponding cycloadducts.

InChI:InChI=1/C8H8O3S/c1-2-12(9,10)11-8-6-4-3-5-7-8/h2-7H,1H2

Upstream product

• 6608-47-5 vinylsulfonyl chloride 
• 139-02-6 sodium phenoxide 
• 1622-32-8 2-Chloroethanesulfonyl chloride 
• 108-95-2 phenol 

Downstream Products

• 28509-28-6 β-tert-Butylperoxyaethylsulfonsaeurephenylester 
• 33912-50-4 4-Phenoxysulfonyl-cyclohex-1-en 
• 28509-29-7 β-(2-Methylpent-2-ylperoxy)-aethylsulfonsaeurephenylester 
• 28509-31-1 2-(1,1-Dimethyl-2-phenyl-ethylperoxy)-ethanesulfonic acid phenyl ester 
• 28509-32-2 2-(1,1-Dimethyl-2-o-tolyl-ethylperoxy)-ethanesulfonic acid phenyl ester 
• 28509-35-5 2-(1,1-Dimethyl-4-phenyl-butylperoxy)-ethanesulfonic acid phenyl ester 
• 28509-33-3 2-[2-(3,5-Dimethyl-phenyl)-1,1-dimethyl-ethylperoxy]-ethanesulfonic acid phenyl ester 
• 28638-30-4 2-(1,1-Dimethyl-2-naphthalen-1-yl-ethylperoxy)-ethanesulfonic acid phenyl ester 
• 28509-34-4 2-(1,1-Dimethyl-3-phenyl-propylperoxy)-ethanesulfonic acid phenyl ester 
• 13023-44-4 2-Methoxy-ethanesulfonic acid phenyl ester 
• 55480-59-6 diphenyl but-1-ene-2,4-disulfonate 
• 1562-37-4 β-<1-Nitro-cyclohexyl>-aethansulfonsaeure-phenylester 
• 433961-87-6 2-{4-[4-((S)-2-Methyl-1-phenyl-propylcarbamoyl)-2-phenyl-quinolin-3-ylmethyl]-piperazin-1-yl}-ethanesulfonic Acid Phenyl Ester 
• 1068599-76-7 C₆H₅OSO₂C₂H₄BO₂C₂(CH₃)4 

Relevant articles and documents

MILD AND PRACTICAL CYCLOADDITION REACTIONS OF FURANS WITH PHENYL VINYL SULFONATE

Phenyl vinyl sulfonate reacts with various alkyl furan derivatives under mild conditions to produce excellent yields of the corresponding cycloadducts.

Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer

In this work, we developed a small library of novel OBHS-RES hybrid compounds with dual inhibition activities targeting both the estrogen receptor α (ERα) and NF-?B by incorporating resveratrol (RES), a known inhibitor of NF-?B, into a privileged indirect antagonism structural motif (OBHS, oxabicycloheptene sulfonate) of estrogen receptor (ER). The OBHS-RES conjugates could bind well to ER and showed remarkable ERα antagonistic activity, and they also exhibited excellent NO inhibition in macrophage RAW 264.7 cells. Compared with 4-hydroxytamoxifen, some of them showed better antiproliferative efficacy in MCF-7 cell lines with IC50 up to 3.7 μM. In vivo experiments in a MCF-7 breast cancer model in Balb/c nude mice indicated that compound 26a was more potent than tamoxifen. Exploration of the compliancy of the structure against ER specificity utilizing these types of isomeric three-dimensional ligands indicated that one enantiomer had much better biological activity than the other.

Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer

A strategy to develop chemotherapeutic agents by combining several active groups into a single molecule as a conjugate that can modulate multiple cellular pathways may produce compounds having higher efficacy compared to that of single-target drugs. In th