1562347-65-2Relevant academic research and scientific papers
Autocatalytic one pot orchestration for the synthesis of α-arylated, α-amino esters
Roche, Stephane P.,Samanta, Shyam S.,Gosselin, Marine M. J.
supporting information, p. 2632 - 2634 (2014/03/21)
A novel acetyl chloride-mediated cascade transformation involving three components (benzyl carbamate, ethyl glyoxylate and arene nucleophiles) is reported. Aryl orthogonally protected α-amino acids are obtained in a one pot cascade, using a mild AcOH-AcCl system, via a critical autocatalytic dehydration-activation step ensuring an original and efficient Friedel-Crafts orchestration. The Royal Society of Chemistry 2014.
