62183-04-4Relevant academic research and scientific papers
Catalytic Asymmetric Mannich Reaction with N-Carbamoyl Imine Surrogates of Formaldehyde and Glyoxylate
You, Yang'en,Zhang, Long,Cui, Linfeng,Mi, Xueling,Luo, Sanzhong
, p. 13814 - 13818 (2017)
N,O-acetals (NOAcs) were developed as bench stable surrogates for N-carbamoyl, (Boc, Cbz and Fmoc) formaldehyde and glyoxylate imines in asymmetric Mannich reactions. The NOAcs can be directly utilized in the chiral primary amine catalyzed Mannich reactions of both acyclic and cyclic β-ketocarbonyls with high yields and excellent stereoselectivity. The current reaction offers a straightforward approach in the asymmetric synthesis of α- or β-amino carbonyls bearing chiral quaternary centers in a practical and highly stereocontrolled manner.
A chiral α - amino acid derivative and its preparation method (by machine translation)
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Paragraph 0093; 0094; 0095; 0098; 0099, (2018/01/03)
The invention discloses a chiral α - amino acid derivative and its preparation method. The invention α - chiral amino acid derivatives, its structural formula shown in formula I: Its preparation method, comprises the following steps: with the carbonyl compound to the N, O - acetal of the mixture with a chiral primary uncle diamine organic small molecule catalyst, strong and weak acid mixing, reaction, to obtain the chiral α - amino acid compounds; the carbonyl compound including aldehyde and/or ketone. The invention chiral α - amino acid ester compound having a simple structure of the chiral primary uncle diamine organic small molecule catalyst catalytic, solvent-free, one-step synthesis, simple, high-efficiency. (by machine translation)
Autocatalytic one pot orchestration for the synthesis of α-arylated, α-amino esters
Roche, Stephane P.,Samanta, Shyam S.,Gosselin, Marine M. J.
, p. 2632 - 2634 (2014/03/21)
A novel acetyl chloride-mediated cascade transformation involving three components (benzyl carbamate, ethyl glyoxylate and arene nucleophiles) is reported. Aryl orthogonally protected α-amino acids are obtained in a one pot cascade, using a mild AcOH-AcCl system, via a critical autocatalytic dehydration-activation step ensuring an original and efficient Friedel-Crafts orchestration. The Royal Society of Chemistry 2014.
