C₂₄H₂₂BrClO₉

Base Information

• Chemical Name: C₂₄H₂₂BrClO₉
• CAS No.: 1562421-66-2
• Molecular Formula: C₂₄H₂₂BrClO₉
• Molecular Weight: 569.79
• Mol file: 1562421-66-2.mol

Synonyms:C₂₄H₂₂BrClO₉

Chemical Property of C₂₄H₂₂BrClO₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₂BrClO₉

There total 8 articles about C₂₄H₂₂BrClO₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2’-bromo-2α-chloropodophyllotoxin (1562422-36-9) + acetic acid (64-19-7,77671-22-8) → C24H22BrClO9 (1562421-66-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1021/jf405316w

Reference yield:

2’-bromo-2α-chloropodophyllotoxin (1562422-36-9) + acetic acid (64-19-7,77671-22-8) → 2'-bromo-dehydrodesoxypodophyllotoxin (60073-37-2) + C24H22BrClO9 (1562421-66-2)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -18 - 20 ℃;

Reference yield:

2′-bromopodophyllotoxin (40456-15-3) → C24H22BrClO9 (1562421-66-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / 2 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.42 h / -78 °C / Inert atmosphere

2.2: 12 h / -78 - 17 °C / Inert atmosphere

2.3: 2 h / 20 °C / pH 5 / Inert atmosphere

3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C

With dmap; dicyclohexyl-carbodiimide; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jf405316w

upstream raw materials:

2’-bromo-2α-chloropodophyllotoxin

acetic acid

podofilox

2′-bromopodophyllotoxin

Refernces

• 1、 Fan, Lingling,Guo, Yong,Zhi, Xiaoyan,Yu, Xiang,Xu, Hui. "Stereoselective synthesis of 2α-chloropicropodophyllotoxins and insecticidal activity of their esters against oriental armyworm, mythimna separata walker". . p. 3726 - 3733. Retrieved 2014/05/20.