1562653-38-6

Basic information

• Product Name: 8-(4-bromophenyl)-4,5-dimethyl-7-phenylpyrimido[4,5-d]pyridazin-2(1H,3H,7H)-one
• Synonyms: 8-(4-bromophenyl)-4,5-dimethyl-7-phenylpyrimido[4,5-d]pyridazin-2(1H,3H,7H)-one
• CAS NO: 1562653-38-6
• Molecular Weight: 409.285
• Mol File: 1562653-38-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 8-(4-bromophenyl)-4,5-dimethyl-7-phenylpyrimido[4,5-d]pyridazin-2(1H,3H,7H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(4-bromophenyl)-4,5-dimethyl-7-phenylpyrimido[4,5-d]pyridazin-2(1H,3H,7H)-one(1562653-38-6)
• EPA Substance Registry System: 8-(4-bromophenyl)-4,5-dimethyl-7-phenylpyrimido[4,5-d]pyridazin-2(1H,3H,7H)-one(1562653-38-6)

Safety Data

• Hazardous Substances Data: 1562653-38-6(Hazardous Substances Data)

Upstream product

• 80352-42-7 1-(4-bromophenyl)-2,2-dihydroxyethanone 
• 123-54-6 acetylacetone 
• 5195-29-9 4-bromophenylglyoxal 
• 1562653-44-4 C₁₄H₁₃BrN₂O₃ 
• 100-63-0 phenylhydrazine 

Relevant articles and documents

Regiospecific strategies for the synthesis of novel dihydropyrimidinones and pyrimidopyridazines catalyzed by molybdate sulfuric acid

The one-pot reactions of aryl glyoxals with acetylacetone and urea using molybdate sulfuric acid (5 mol %) lead to the novel functionalized 5-acetyl-4-(aryloyl)-3,4-dihydropyrimidinones, which readily undergo the Knorr condensation with hydrazines to produce new pyrimido[4,5-d]pyridazines. The present strategies are in accordance with green chemistry principles through the use of a safe and recyclable catalyst under solvent-free conditions.

Novel tri- and tetra-substituted pyrimido[4,5-d]pyridazines: Regiospecific synthesis catalyzed by silica supported yttrium trinitrate

Novel tri- and tetra-substituted pyrimido[4,5-d]pyridazines-2(1H,3H,7H)- ones have been synthesized via the regiospecific condensation reaction of hydrazine derivatives with 5-acetyl-4-aryloyl-6-methyl-3,4-dihydropyrimidinones in the presence of SiO2-Y(NO3)3 as a green and recyclable catalyst under solvent-free conditions. All products were obtained in high yields and short reaction time. Employing this method is in accord with green chemistry principles.