80352-42-7

Basic information

• Product Name: 4-Bromophenylglyoxal hydrate
• Synonyms: 4-BROMOPHENYLGLYOXAL HYDRATE;4-Bromophenylglyoxal hydrate 95%;4-BROMOPHENYLGLYOXAL HYDRATE, 95+%;1-(4-Bromophenyl)-2,2-dihydroxyethanone;Ethanone, 1-(4-bromophenyl)-2,2-dihydroxy-;(4-Bromophenyl)(oxo)acetaldehyde hydrate;4-Bromophenylglyoxal
• CAS NO: 80352-42-7
• Molecular Formula: C₈H₇BrO₃
• Molecular Weight: 231.04
• Mol File: 80352-42-7.mol
• Article Data: 39

Chemical Properties

• Melting Point: 132°C
• Boiling Point: 340 °C at 760 mmHg
• Flash Point: 159.4 °C
• Appearance: /
• Density: 1.743g/cm³
• Vapor Pressure: 3.42E-05mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: 2-8°C
• PKA: 10.42±0.41(Predicted)
• CAS DataBase Reference: 4-Bromophenylglyoxal hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromophenylglyoxal hydrate(80352-42-7)
• EPA Substance Registry System: 4-Bromophenylglyoxal hydrate(80352-42-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 80352-42-7(Hazardous Substances Data)

Usage

General Description

4-Bromophenylglyoxal hydrate is a chemical compound with the molecular formula C8H7BrO3. It is a derivative of phenylglyoxal and contains a bromine atom attached to a phenyl group. 4-Bromophenylglyoxal hydrate is often used in organic synthesis and as a reagent in various chemical reactions. It is known for its ability to act as a precursor in the synthesis of heterocyclic compounds and as a starting material for the preparation of pharmaceuticals and agrochemicals. 4-Bromophenylglyoxal hydrate is also used in research and development activities in the fields of chemistry, medicine, and material science due to its distinctive chemical properties and potential applications.

InChI:InChI=1/C8H7BrO3/c9-6-3-1-5(2-4-6)7(10)8(11)12/h1-4,8,11-12H

Upstream product

• 99-90-1 para-bromoacetophenone 
• 5195-29-9 4-bromophenylglyoxal 
• 49615-87-4 2-(4-bromophenyl)-2-oxoacetaldehyde oxime 

Downstream Products

• 1428646-99-4 1-(4-bromobenzoyl)-3-((4-methoxyphenyl)thio)-9-oxo-9H-indeno[2,1-c]pyridine-4-carbonitrile 
• 1562653-38-6 8-(4-bromophenyl)-4,5-dimethyl-7-phenylpyrimido[4,5-d]pyridazin-2(1H,3H,7H)-one 
• 1610411-21-6 4-(5-(4-bromophenyl)-3-cyclopropyl-1-phenyl-1,6-dihydropyrrolo[2,3-c]pyrazol-4-yl)-3-cyclopropyl-1-phenyl-1H-pyrazol-5-amine 
• 1610411-17-0 4-(5-(4-bromophenyl)-3-methyl-1-(p-tolyl)-1,6-dihydropyrrolo-[2,3-c]pyrazol-4-yl)-3-methyl-1-(p-tolyl)-1H-pyrazol-5-amine 
• 1610411-11-4 4-(5-(4-bromophenyl)-3-methyl-1-phenyl-1,6-dihydropyrrolo[2,3-c]pyrazol-4-yl)-3-methyl-1-phenyl-1H-pyrazol-5-amine 
• 1610411-26-1 4-(5-(4-bromophenyl)-1-methyl-3-(thiophen-2-yl)-1,6-dihydropyrrolo[2,3-c]pyrazol-4-yl)-1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine 
• 1610411-05-6 (3,7-dimethyl-1,9-bis(thiophen-2-yl)-3,4,5,6,7,10-hexahydrodipyrazolo[3,4-d:4',3′-g][1,3]diazocine-5,10-diyl)bis((4-bromophenyl)methanone) 
• 1610410-99-5 (1,9-bis(4-chlorophenyl)-3,7-dimethyl-3,4,5,6,7,10-hexahydrodipyrazolo[3,4-d:4',3'-g][1,3]diazocine-5,10-diyl)bis((4-bromophenyl)methanone) 
• 1610410-92-8 (3,7-dimethyl-1,9-diphenyl-3,4,5,6,7,10-hexahydrodipyrazolo-[3,4-d:4',3'-g][1,3]diazocine-5,10-diyl)bis((4-bromophenyl)methanone) 
• 1610410-87-1 5,10-bis(4-bromophenyl)-1,9-dicyclopropyl-3,7-dimethyl-3,7-dihydrodipyrazolo[3,4-b:4′,3′-f ][1,7]naphthyridine 
• 1610410-80-4 5,10-bis(4-bromophenyl)-1,3,7,9-tetramethyl-3,7-dihydrodipyrazolo[3,4-b:4′,3′-f ][1,7]naphthyridine 
• 1591952-95-2 C₂₀H₁₆Br₂N₄O₂ 
• 1591952-94-1 C₂₀H₁₆BrClN₄O₂ 
• 1591952-93-0 C₂₁H₁₉BrN₄O₂ 

Relevant articles and documents

One-pot, three-component synthesis of polyfunctionalized benzo[h]pyrazolo[3,4-b][1,6]naphthyridine and benzo[g]pyrazolo[3,4-b]quinoline derivatives in the presence of silver nanoparticles (AgNPs)

An efficient and straightforward protocol for one-pot, three-component reaction of aryl glyoxal monohydrates 1a-h, 5-amino-1-aryl-3-methylpyrazoles 2a,b and 4-hydroxyquinoline-2(1H)-one (3) or 2-hydroxy-1,4-naphthoquinone (4) using silver nanoparticles (AgNPs) as a high performance nanocatalyst in H2O/EtOH at 60°C afforded the corresponding polyfunctionalized benzo[h]pyrazolo[3,4-b][1,6]naphthyridines 5a-h and benzo[g]pyrazolo[3,4-b]quinolines 6a-i, respectively. Excellent catalytic activity, high yields, employing green media and green nanocatalyst, cost-effective and simple procedure are some notable advantages of using AgNPs as a noble metal nanocatalyst in this synthetic strategy. The structures of fused heterocycles were confirmed by their Fourier transform infrared, proton nuclear magnetic resonance (1H-NMR), and 13C-NMR spectral data and microanalysis.

Synthesis of Ethyl 2-Amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates by a One-pot, Three-Component Reaction in the Presence of TPAB

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, 1H-NMR, and 13C-NMR spectral data and elemental analysis.

Synthesis of 4-Hydroxy-3-(2-arylimidazo[1,2-a]pyridin-3-yl)quinolin-2(1H)-ones in the Presence of DABCO as an Efficient Organocatalyst

The one-pot, three-component, synthesis of a new series of 4-hydroxy-3-(2-arylimidazo[1,2-a]pyridin-3-yl)quinolin-2(1H)-ones in the presence of DABCO as a catalyst has been achieved using aryl glyoxal monohydrates, quinoline-2,4(1H,3H)-dione, and 2-aminopyridine in H2O/EtOH under reflux conditions. The cheapness of organocatalyst, simple workup, operational simplicity, regioselectivity, and high yields are some advantages of this protocol.