156294-51-8

Basic information

• Product Name: 7-triethylsilyl-10-benzoyl-10-deacetylbaccatin III
• Synonyms: 7-triethylsilyl-10-benzoyl-10-deacetylbaccatin III
• CAS NO: 156294-51-8
• Molecular Weight: 762.97
• Mol File: 156294-51-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-triethylsilyl-10-benzoyl-10-deacetylbaccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 7-triethylsilyl-10-benzoyl-10-deacetylbaccatin III(156294-51-8)
• EPA Substance Registry System: 7-triethylsilyl-10-benzoyl-10-deacetylbaccatin III(156294-51-8)

Safety Data

• Hazardous Substances Data: 156294-51-8(Hazardous Substances Data)

Upstream product

• 994-30-9 triethylsilyl chloride 
• 32981-86-5 10-deacetylbaccatin III 
• 98-88-4 benzoyl chloride 
• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 

Downstream Products

• 848251-57-0 7-triethylsilyl-10-deacetyl-10-benzoyl-13-acetylbaccatin III 
• 1054669-71-4 C₃₈H₄₂O₁₂ 

Relevant articles and documents

Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents

A series of novel taxane-based multidrug resistance (MDR) reversal agents (TRAs) has been designed and synthesized. Structure - activity relationship (SAR) study clearly indicates that modification of the C-7 position with hydrophobic arenecarbonylcinnamoyl groups brings about high potency against drug efflux mediated by P-glycoprotein (P-gp). Six TRAs exhibit ability to modulate a wide range of ATP-binding cassette (ABC) transporters, such as P-gp, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP), which may serve as novel broad-spectrum modulators of ABC transporters.