156300-79-7Relevant academic research and scientific papers
DERIVATIVE OF BUTYLPHTHALIDE AND PREPARATION METHOD AND USE THEREOF
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Paragraph 0029, (2014/09/02)
(-)-(S)-3-(3'-hydroxy)-butylphthalide (a compound shown by Formula I) and an ester formed of the same and an acid are proved by experiments to be applicable to treatment and prevention of cerebral ischemic diseases and have a sleep-improving function. The acid refers to a pharmaceutically acceptable inorganic or organic acid. The inorganic acid refers to nitric acid, sulfuric acid, or phosphoric acid. In addition to an acid radical, the organic acid at least comprises at least one of an amino group, a hydroxyl group, and a carboxyl group. None of the compound shown by Formula I and the ester thereof is water-soluble. An ester generated from the compound and the acid further react with an acid or a base to generate a salt which is water-soluble and is used to prepare injection preparation. The experiment proves that the salt does not stimulate vessels.
Synthesis of aromatic spiroacetals
Brimble, Margaret A.,Horner, Gillian M.,Stevenson, Ralph J.
, p. 189 - 196 (2007/10/03)
The synthesis of aromatic spiroacetal ring systems related to the papulacandins is reported. ortho-Metalation of diisopropylbenzamide, followed by reaction with the electrophiles δ-valerolactone. γ-butyrolactone and γ-valerolactone, provided the keto alcohol adducts (10), (16) and (21) respectively. Reduction of the ketone followed by treatment with acid afforded phthalides (12), (18) and (23). Finally oxidative cyclization with iodobenzene diacetate provided the spiroacetals (7), (14) and (19).
Directed Ortho Metalations of Tertiary Benzamides Using Lactones as Electrophiles
Brenstrum, Timothy J.,Brimble, Margaret A.,Stevenson, Ralph J.
, p. 4897 - 4904 (2007/10/02)
Directed ortho metalation of oxygenated tertiary benzamides using tert-butyllithium in THF/TMEDA at -78 deg C followed by the addition of a range of lactones afforded ortho-substituted keto-alcohols in good yield.
