1563242-87-4Relevant articles and documents
Synthesis of alkaloid pulmonarin B and its application in the prevention and control of plant viruses and mycosis
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Paragraph 0020, (2022/01/20)
The present invention relates to the efficient synthesis of the alkaloid pulmonarin B and its application in the prevention and control of plant viruses and pathogenic diseases, the present invention is based on the systematic research literature, drawing
Isolation and synthesis of pulmonarins A and B, acetylcholinesterase inhibitors from the colonial ascidian Synoicum pulmonaria
Tadesse, Margey,Svenson, Johan,Sepcic, Kristina,Trembleau, Laurent,Engqvist, Magnus,Andersen, Jeanette H.,Jaspars, Marcel,Stensvaisg, Klara,Haug, Tor
, p. 364 - 369 (2014/03/21)
Pulmonarins A and B are two new dibrominated marine acetylcholinesterase inhibitors that were isolated and characterized from the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast. The structures of natural pulmonarins A and B were tentatively elucidated by spectroscopic methods and later verified by comparison with synthetically prepared material. Both pulmonarins A and B displayed reversible, noncompetitive acetylcholinesterase inhibition comparable to several known natural acetylcholinesterase inhibitiors. Pulmonarin B was the strongest inhibitor, with an inhibition constant (K i) of 20 μM. In addition to reversible, noncompetitive acetylcholinesterase inhibition, the compounds displayed weak antibacterial activity but no cytotoxicity or other investigated bioactivities.