89936-29-8

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 212688-03-4 3,5-dibromo-4-methoxy-phenyl acetic acid methyl ester 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 212688-02-3 3,5-dibromo-4-hydroxyphenylacetic acid methyl ester 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 15964-81-5 methyl 3-hydroxy-4-methoxyphenylacetate 
• 89936-31-2 methyl [3,5-bis(tert-butyldimethylsilyloxy)-4-methoxyphenyl]acetate 
• 1131-94-8 homoisovanillic acid 
• 34021-73-3 (3,5-dihydroxy-4-methoxyphenyl)acetic acid 
• 89936-30-1 2-(3-bromo-5-hydroxy-4-methoxyphenyl)acetic acid 
• 1007893-78-8 (3,5-dibromo-4-hydroxyphenyl)(9H-pyrido[3,4-b]indol-1-yl)methanone 
• 1007893-79-9 (6-bromo-9H-pyrido[3,4-b]indol-1-yl)(3,5-dibromo-4-hydroxyphenyl)methanone 
• 1007893-80-2 (7-bromo-9H-pyrido[3,4-b]indol-1-yl)(3,5-dibromo-4-hydroxyphenyl)methanone 

Relevant academic research and scientific papers

Synthesis of alkaloid pulmonarin B and its application in the prevention and control of plant viruses and mycosis

The present invention relates to the efficient synthesis of the alkaloid pulmonarin B and its application in the prevention and control of plant viruses and pathogenic diseases, the present invention is based on the systematic research literature, drawing

Total synthesis of pulmonarin B and design of brominated phenylacetic acid/tacrine hybrids: Marine pharmacophore inspired discovery of new CHE and Aβ aggregation inhibitors

A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogues were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay results revealed that 1 showed moderate dual acetylcholinesterase (AChE)/ butyrylcholinesterase (BChE) inhibitory activity, while the hybrid 12j proved to be the most potent dual inhibitor among the designed derivatives, being almost as active as tacrine. Molecular modeling studies together with kinetic analysis suggested that 12j interacted with both the catalytic active site and peripheral anionic site of AChE. Compounds 1 and 12j could also inhibit self-induced and AChE-induced Aβ aggregation. In addition, the cell-based assay against the human hepatoma cell line (HepG2) revealed that 1 and 12j did not show significant hepatotoxicity compared with tacrine and donepezil. Taken together, the present study confirmed that compound 1 was a potential anti-Alzheimer’s disease (AD) hit, and 12j could be highlighted as a multifunctional lead compound for anti-AD drug development.

Total syntheses of eudistomins Y1-Y7 by an efficient one-pot process of tandem benzylic oxidation and aromatization of 1-benzyl-3,4-dihydro-β-carbolines

The first total synthesis of eudistomin Y7 (7) and total syntheses of eudistomins Y1-Y6 (1-6) are described. An efficient room-temperature conversion of 1-benzyl-3,4-dihydro-β-carbolines (11) into 1-benzoyl-β-carbolines (14) by a one-pot process of tandem benzylic oxidation and aromatization as the key step of these total syntheses was also studied in detail. The first total synthesis of eudistomin Y 7 (7) and total syntheses of eudistomins Y1-Y6 (1-6) are described. An efficient room-temperature conversion of 1-benzyl-3,4-dihydro-β-carbolines (11) into 1-benzoyl-β-carbolines (14) by a one-pot process of tandem benzylic oxidation and aromatization as the key step of these total syntheses was also studied in detail. Copyright

Syntheses of the marine metabolites verongamine, hemibastadin-2, and aerothionin using the cyano ylide coupling methodology

Syntheses of the marine metabolites verongamine, hemibastadin-2, and aerothionin have been accomplished by a methodology involving the conversion of a carboxylic acid to an acyl cyano phosphorane which may be oxidized to an α,β-diketo nitrile. This strong