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Upstream product

• 4265-49-0 α,α'-(benzylidenedithio)diacetic acid 
• 100-52-7 benzaldehyde 
• 68-11-1 mercaptoacetic acid 

Relevant academic research and scientific papers

Silica gel-promoted new one-pot procedure for the synthesis of 1,3-oxathiolan-5-one

A highly selective two-component silica gel-promoted synthesis of 1,3-oxathiolan-5-one derivatives in N,N-Dimethylformamide (DMF) is presented. The reaction was carried out using aromatic aldehyde and mercaptoacetic acid in the presence of silica gel in DMF with heating. The reactions were worked up by separating the silica gel and recovering the solid product after adding water in excellent yields without any chromatographic purification. Structures of the compounds were satisfactorily confirmed by 1H NMR and LCMS spectral analysis.

Cobalt doped ZnS nanoparticles as a recyclable catalyst for solvent-free synthesis of heterocyclic privileged medicinal scaffolds under infrared irradiation

This paper reports preparation and characterization of cobalt doped ZnS NPs and their catalytic application in the synthesis of heterocyclic privileged medicinal scaffolds involving pyrazolones (with excellent regioselectivity) and 1,3-oxathiolan-5-one frameworks under infrared irradiation. Nanoparticles have been prepared at room temperature by a wet chemical method. The heterogeneous catalysts were fully characterized by XRD, TEM, EDAX, ICP-AES and UV/Vis. Under infrared radiation (IR), the catalytic activity of Co doped ZnS NPs was about 40-fold higher under IR as compared to the conventional method. Nanocatalyst plays a dual role of catalyst as well as susceptor, and enhances the overall capacity to absorb IR in the reaction mixture. Doping by Co promotes the activity and selectivity of ZnS NPs as indicated by their high TOF value, providing the products with good to excellent yields. The surface acidity of NPs was measured by FTIR spectra of chemisorbed pyridine. The present method does not involve any hazardous organic solvent or catalyst. The introduction of nanocatalyst in an IR system offers promising features for the reaction response such as the shorter reaction time, simple work-up procedure, and purification of products by non-chromatographic methods. The catalyst was reused up to four runs without an appreciable loss of catalytic activity.

Molecular iodine in [bmim][BF4]: A highly efficient green catalytic system for one-pot synthesis of 1,3-oxathiolan-5-one

Aldehydes and mercaptoacetic acid are coupled in the presence of a catalytic amount of economical and non-toxic molecular iodine in [bmim][BF 4] ionic liquid under mild conditions to afford the corresponding 1,3-oxathiolan-5-one in excellent yields. Molecular iodine acts faster in ionic liquids when compared to conventional solvents such as DMSO, DMF, ethyl acetate, and acetonitrile. The recovered ionic liquids can be recycled in subsequent reactions with consistent activity.

Electrolytic partial fluorination of organic compounds. 30.1 Drastic improvement of anodic monofluorination of 2-substituted 1,3-oxathiolan-5- ones using the novel fluorine source Et4NF·4HF

The highly regioselective anodic monofluorination of 2-substituted 1,3- oxathiolan-5-ones was successfully carried out using a novel supporting electrolyte, Et4NF·4HF, while use of a conventional supporting electrolyte, Et3N·3HF, resulted in no formation or extremely low yields of the fluorinated products.

142. Praeparative chromatographische Enantiomerentrennung von synthetisch nuetzlichen cyclischen Acetalen

Preparative Chromatographic Resolution of Sunthetically Useful Cyclic Acetals Racemic cyclic acetals derived from aldehydes and glycine, glycolic acid, thioglycolic acid, formylacetic acid, and acetoacetic acid (oxazolidinones 4-13, dioxolanones 14,15, ox