156459-21-1

Basic information

• Product Name: 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid
• CAS NO: 156459-21-1
• Molecular Weight: 167.121
• Mol File: 156459-21-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid(156459-21-1)
• EPA Substance Registry System: 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid(156459-21-1)

Safety Data

• Hazardous Substances Data: 156459-21-1(Hazardous Substances Data)

Upstream product

• 156459-19-7 3-cyano-6-(dimethoxymethyl)-2-pyridone 
• 156459-20-0 6-(dimethoxymethyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid 

Relevant articles and documents

An efficient synthesis of 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid and some carbonyl derivatives of it and its 6-acetyl homologue

Starting with 1,1-dimethoxy-2-propanone (1), 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid (5a) has been prepared in large quantities by a highly efficient, 4-step synthesis. This compound, along with its one carbon homologue, 6-acetyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid (5b) has been reacted with several carbonyl derivative forming reagents to provide a series of side chains for β-lactams. Among these carbonyl derivatives are styrylamides which were prepared from Wittig and Horner-Emmons reagents. The preparation of the phosphonium salts and phosphonate esters is also described.