156482-75-6 Usage
Uses
Used in Pharmaceutical Industry:
2-(2-methoxy-1-naphthyl)ethanamine(SALTDATA: HCl) is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its unique chemical structure allows it to be a key component in the creation of compounds that target specific biological pathways and receptors, contributing to the development of novel therapeutic agents.
Used in Central Nervous System Disorders Treatment:
In the field of neurology and psychiatry, 2-(2-methoxy-1-naphthyl)ethanamine(SALTDATA: HCl) is studied for its potential therapeutic effects in treating central nervous system disorders. Its ability to interact with specific neurotransmitter systems and modulate neuronal activity makes it a promising candidate for the management of conditions such as anxiety, depression, and certain neurological diseases.
Used in Drug Development Research:
2-(2-methoxy-1-naphthyl)ethanamine(SALTDATA: HCl) is utilized in research settings as a starting material or a scaffold for the design and synthesis of new drug candidates. Its chemical properties and structural features provide a foundation for the exploration of innovative therapeutic agents, enhancing the drug discovery process and contributing to the advancement of medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 156482-75-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,4,8 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 156482-75:
(8*1)+(7*5)+(6*6)+(5*4)+(4*8)+(3*2)+(2*7)+(1*5)=156
156 % 10 = 6
So 156482-75-6 is a valid CAS Registry Number.
156482-75-6Relevant academic research and scientific papers
Design and Synthesis of New Naphthalenic Derivatives as Ligands for 2-Iodomelatonin Binding Sites
Langlois, Michel,Bremont, Beatrice,Shen, Shuren,Poncet, Annie,Andrieux, Jean,et al.
, p. 2050 - 2060 (2007/10/02)
New melatonin-like agents were designed from the frameworks of 2,5-dimethoxyphenethylamine, an important structural moiety for the 5-HT receptor, and (2-methoxynaphthyl)ethylamine.The compounds were synthesized by classical methods and evaluated in binding assays with chicken brain membranes using 2-(125I>iodomelatonin as the radioligand.Preliminary studies on the series of N-acyl-disubstituted phenethylamines showed the favorable role of the methoxy group in the ortho position of the side chain on the affinity for the receptor ( Ki = 8 +/- 0.2 nM ) for N-propionamide (3o).This effect was confirmed in a series of the naphthalene derivatives, a bioisosteric moiety of the indole ring, and several potent ligands for melatonin binding sites were prepared such as N-propionamide (4b) ( Ki = 0.67 +/- 0.05 nM ) and N-cyclopropylformamide (Ki = 0.05 +/- 0.004 nM ( (4k).Structure-activity relationships are discussed with regard to melatonin and bioisosteric naphthalenic compound 2.The Ki value for 4b was affected to a similar extent to that of melatonin by GTP-γ-S or Mn2+ in competition experiments, suggesting an agonist profile for this compound.
