156539-36-5Relevant academic research and scientific papers
A Facile Method to Append Peptidal Side-Chains onto Steroidal Templates
Horwell, David C.,Lennon, Ian C.,Roberts, Edward
, p. 4225 - 4234 (1994)
Side-Chains corresponding to phenylalanine, tyrosine and tryptophan are introduced onto a steroid template in a highly efficient manner via a condensation of the appropriate lithium acetylide with a steroidal ketone.The subsequent acetylene functionality can be selectively reduced in the presence of a modified benzyl ether and steroid ring unsaturation.
