A Facile Method to Append Peptidal Side-Chains onto Steroidal Templates

Article abstract of DOI:10.1016/S0040-4020(01)86716-8

Side-Chains corresponding to phenylalanine, tyrosine and tryptophan are introduced onto a steroid template in a highly efficient manner via a condensation of the appropriate lithium acetylide with a steroidal ketone.The subsequent acetylene functionality can be selectively reduced in the presence of a modified benzyl ether and steroid ring unsaturation.