Tetrahedron p. 4225 - 4234 (1994)
Update date:2022-09-26
Topics:
Horwell, David C.
Lennon, Ian C.
Roberts, Edward
Side-Chains corresponding to phenylalanine, tyrosine and tryptophan are introduced onto a steroid template in a highly efficient manner via a condensation of the appropriate lithium acetylide with a steroidal ketone.The subsequent acetylene functionality can be selectively reduced in the presence of a modified benzyl ether and steroid ring unsaturation.
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