156557-88-9

Upstream product

• 135214-81-2 (1R,3R,5R)-2-azabicyclo<3.3.0>octane-3-carboxylic acid hydrochloride 
• 501-53-1 benzyl chloroformate 
• 129101-19-5 (all-R)-2-Azabicyclo[3.3.0]octan-3-oic acid benzyl ester p-toluenesulfonate 
• 138877-09-5 (1R,3R,5R)-benzyl 2-azabicyclo<3.3.0>octane-3-carboxylate hydrochloride 
• 128900-19-6 (1R,3R,5R)-2-azabicyclo<3.3.0>octane-3-carboxylic acid 

Downstream Products

• 156481-90-2 (all-R)-2-(Benzyloxycarbonyl)-2-azabicyclo<3.3.0>octan-3-carbonsaeure-pyrrolidid 
• 156481-92-4 (2S,1'R,3'R,5'R)-2'-(Benzyloxycarbonyl)-2'-azabicyclo<3.3.0>octan-3'-carbonsaeure-2-(methoxymethyl)pyrrolidid 
• 185420-82-0 (2R,3aR,6aR)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic acid dimethylamide 
• 156481-95-7 (all-R)-2-Azabicyclo<3.3.0>octan-3-carboxamid 
• 183021-38-7 (2R,3aR,6aR)-2-((3aR,6aR)-Hexahydro-cyclopenta[b]pyrrole-1-carbonyl)-hexahydro-cyclopenta[b]pyrrole-1-carboxylic acid benzyl ester 
• 156481-94-6 (all-R)-2-(Benzyloxycarbonyl)-2-azabicyclo<3.3.0>octan-3-carboxamid 

Relevant academic research and scientific papers

HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES

The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein

Hydroxamate-Based Inhibitors of Deacetylases

The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein.

Chemical differentiation of enantiotopic groups: Diastereoselective opening of a prochiral dilactone

Prochiral dilactone 1 has been synthesized and subjected to diastereoselective nucleophilic opening. The structural features of chiral, enantiomerically pure nucleophiles have been optimized regarding their capability to perform prochiral recognition at dilactone 1. 3-Ketoglutaric mono acid products 2 of dilactone opening, which are versatile building blocks for natural product synthesis, have been obtained in diastereomeric ratios up to 84:16 and were enriched by subsequent crystallization to 97.5:2.5.

Utilization of Industrial Waste Materials, 1. - Synthesis of New Primary and Secondary Chiral 1,2-Diamines

Primary and secondary 1,2-diamines with three or four stereogenic centers were synthesized starting from the benzyl ester of the bicyclic proline analogue (all-R)-2-azabicyclooctane-3-carboxylic acid by a four- or five-step procedure.This is an example for the utilization of the industrial waste material (all-R)-2b. - Key Words: 1,2-Diamines / 2-Azabicyclooctanes / Proline analogue / Cyclopentapyrroles