135214-81-2

Upstream product

• 97475-97-3 ethyl octahydrocyclopenta[b]pyrrole-2-carboxylate 
• 7148-07-4 1-pyrrolidinocyclopent-1-ene 
• 87269-85-0 (±)-methyl 2-(acetylamino)-3-(2-oxocyclopentyl)-propionate 
• 93661-93-9 2,3,3a,4,5,6-Hexahydro-cyclopenta[b]pyrrole-2-carboxylic acid; hydrochloride 
• 97475-96-2 ethyl 1-Benzyl-1,4,5,6-Tetrahydrocyclopenta[b]Pyrrole-2-Carboxylate 
• 2611-03-2 2-chlorocyclopent-1-ene-1-carbaldehyde 

Downstream Products

• 156557-88-9 (1R,3R,5R)-2-(benzyloxycarbonyl)-2-azabicyclo<3.3.0>octane-3-carboxylic acid 
• 129939-63-5 ramipril 
• 87333-19-5 Ramipril 
• 87269-87-2 cis,endo-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester hydrochloride 
• 93779-32-9 (S)-2-Benzyloxycarbonylamino-3-phenyl-propionic acid; compound with (2S,3aS,6aS)-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester 
• 109428-53-7 (2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid 
• 87269-87-2 (1RS,3RS,5RS)-2-Azabicyclo<3.3.0>octan-3-carbonsaeurebenzylester-hydrochlorid 
• 185420-81-9 (2R,3aR,6aR)-2-Dimethylcarbamoyl-hexahydro-cyclopenta[b]pyrrole-1-carboxylic acid benzyl ester 
• 185420-82-0 (2R,3aR,6aR)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic acid dimethylamide 
• 133616-95-2 (1RS,5RS,3'R)-2-Carbamoyl-(3'-methylphenyl)-2-azabicyclo<3.3.0>octan 
• 133696-29-4 (1R,5R)-2-(1-Cyclohexen-1-yl)-2-azabicyclo<3.3.0>octan 

Relevant academic research and scientific papers

A PROCESS FOR PREPARATION OF RAMIPRIL

Disclosed herein is a process for preparation of Ramipril; which comprises; reacting salts of (S,S,S)-azabicyclo[3.3.0]-octane-3-carboxylate with N-[l-(S)-ethoxy carbonyl)-3- phenyl propyl] -L-alanine in presence of dicyclohexylcarbodimide (DCC) and 1- hydroxybenzotriazole (HOBT) in a suitable solvent medium.

EINE EINFACHE DIASTEREOSELEKTIVE SYNTHESE VON (1SR,3SR,5SR)-2-AZABICYCLOOCTAN-3-CARBONSAEURE

(1SR,3SR,5SR)-2-Azabicyclooctane-3-carboxylic acid, precursor of the angiotensin-converting-enzyme-inhibitor Hoe 498, is easily prepared from 1-chloro-1-cyclopentene-2-carbaldehyde in three steps.

SYNTHESIS OF UNNATURAL AMINO ACIDS: (S,S,S)-2-AZABICYCLOOCTANE-3-CARBOXYLIC ACID

(S,S,S)-2-Azabicyclooctane-3-carboxylic acid 1, a structural element of the very potent ACE inhibitor HOE 498, is readily available via a diastereo selective synthesis starting from serine or cystine.

Synthesis of a highly active angiotensin converting enzyme inhibitor: 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2-azabicyc lo[3.3.0]octane-3-carboxylic acid (Hoe 498)

The convergent, diastereoselective synthesis of 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2-azabicyc lo[3.3.0]octane-3-carboxylic acid (Hoe 498), a new ACE-inhibitor with improved bioavailability and pharmacokinetics, is described.