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156570-16-0

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156570-16-0 Usage

General Description

1-(Difluoromethoxy)-4-(trifluoromethyl)benzene is a chemical compound with the molecular formula C8H5F5O. It is a colorless liquid with a molecular weight of 186.1 g/mol. 1-(Difluoromethoxy)-4-(trifluoromethyl)benzene is often used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of various polymers and materials. It is known for its high reactivity and can undergo various chemical reactions such as halogenation, hydrogenation, and nitration. Additionally, it has been reported to have potential applications in the field of organic chemistry and as a building block for the preparation of complex molecules. Overall, 1-(Difluoromethoxy)-4-(trifluoromethyl)benzene is a versatile chemical that has a wide range of potential uses in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 156570-16-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,5,7 and 0 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 156570-16:
(8*1)+(7*5)+(6*6)+(5*5)+(4*7)+(3*0)+(2*1)+(1*6)=140
140 % 10 = 0
So 156570-16-0 is a valid CAS Registry Number.

156570-16-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(difluoromethoxy)-4-(trifluoromethyl)benzene

1.2 Other means of identification

Product number -
Other names 4-(difluoromethoxy)benzotrifluoride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:156570-16-0 SDS

156570-16-0Downstream Products

156570-16-0Relevant articles and documents

Difluoromethyl bioisostere: Examining the lipophilic hydrogen bond donor concept

Zafrani, Yossi,Yeffet, Dina,Sod-Moriah, Gali,Berliner, Anat,Amir, Dafna,Marciano, Daniele,Gershonov, Eytan,Saphier, Sigal

, p. 797 - 804 (2017/02/05)

There is a growing interest in organic compounds containing the difluoromethyl group, as it is considered a lipophilic hydrogen bond donor that may act as a bioisostere of hydroxyl, thiol, or amine groups. A series of difluoromethyl anisoles and thioanisoles was prepared and their druglike properties, hydrogen bonding, and lipophilicity were studied. The hydrogen bond acidity parameters A (0.085-0.126) were determined using Abraham's solute 1H NMR analysis. It was found that the difluoromethyl group acts as a hydrogen bond donor on a scale similar to that of thiophenol, aniline, and amine groups but not as that of hydroxyl. Although difluoromethyl is considered a lipophilicity enhancing group, the range of the experimental Δlog P(water-octanol) values (log P(XCF2H) - log P(XCH3)) spanned from -0.1 to +0.4. For both parameters, a linear correlation was found between the measured values and Hammett σ constants. These results may aid in the rational design of drugs containing the difluoromethyl moiety.

18F-Labeling of Aryl-SCF3, -OCF3 and -OCHF2 with [18F]Fluoride

Khotavivattana, Tanatorn,Verhoog, Stefan,Tredwell, Matthew,Pfeifer, Lukas,Calderwood, Samuel,Wheelhouse, Katherine,Leecollier, Thomas,Gouverneur, Vronique

supporting information, p. 9991 - 9995 (2015/08/19)

We report that halogenophilic silver(I) triflate permits halogen exchange (halex) nucleophilic 18F-fluorination of aryl-OCHFCl, -OCF2Br and -SCF2Br precursors under mild conditions. This AgI-mediated process allows for the first time access to a range of 18F-labeled aryl-OCHF2, -OCF3 and -SCF3 derivatives, inclusive of [18F]riluzole. The 18F-labeling of these medicinally important motifs expands the radiochemical space available for PET applications. A halogen exchange (halex) 18F-fluorination process offers access for the first time to 18F-labeled arylOCF3, arylOCHF2 and arylSCF3, three motifs of established medicinal importance in PET radiotracers. The use of silver(I) triflate is critical to permit 18F-labeling under mild conditions.

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