73823-79-7

Upstream product

• 94771-81-0 Acetic acid 2-[4-(1-hydroxy-ethyl)-phenyl]-ethyl ester 
• 75-36-5 acetyl chloride 
• 103-45-7 acetic acid phenethyl ester 
• 108-24-7 acetic anhydride 
• 60-12-8 2-phenylethanol 

Downstream Products

• 99215-51-7 1-<4-(1-hydroxyethyl)phenyl>ethanone 
• 156589-16-1 2-(4-acetyl-2-nitrophenyl)ethyl acetate 
• 705939-53-3 C₁₄H₁₃F₃O₄ 
• 705939-70-4 C₁₄H₁₄F₂O₄ 
• 501-94-0 p-hydroxyphenethyl alcohol 
• 60037-42-5 2-(4-acetoxyphenyl)ethyl acetate 
• 1361414-32-5 4-(2-bromoacetyl)phenethyl acetate 
• 22532-49-6 4-ethylphenethylacetate 
• 705939-55-5 C₁₃H₁₁F₅O₃ 
• 705939-56-6 C₁₄H₁₆O₅ 
• 82099-82-9 Acetic acid 4-(2-methoxy-ethyl)-phenyl ester 
• 99215-52-8 4-ethoxyethylacetophenone 
• 93205-89-1 4-methoxyethylacetophenone 
• 88318-14-3 4-(2-ethoxyethyl)phenol 

Relevant academic research and scientific papers

Synthesis method of p-hydroxyphenethyl alcohol

The invention discloses a method for synthesizing p-hydroxyphenethyl alcohol from phenethyl alcohol as a raw material. The method comprises the steps as follows: firstly, phenethyl alcohol and acid anhydride are subjected to an esterification reaction to obtain phenethyl alcohol ester; then, phenethyl alcohol ester and acid anhydride are subjected to an electrophilic substitution reaction under the action of a catalyst and a catalyst promoter to obtain 4-acryl phenethyl alcohol ester; next, 4-acryl phenethyl alcohol ester and hydrogen peroxide are subjected to a Baeyer-Villiger oxidation reaction under the action of organic acid and an oxidation catalyst to obtain 4-acyloxy phenethyl alcohol ester; finally, the 4-acyloxy phenethyl alcohol ester is subjected to a hydrolysis reaction in alkaline water to obtain p-hydroxyphenethyl alcohol. The process for synthesizing p-hydroxyphenethyl alcohol has the advantages that raw materials are widely sourced, the yield is high, the process is concise, few three wastes are produced and industrialization is easy to realize.

NOVEL COMPOUNDS

Disclosed are retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.

(1, 10B-DIHYDRO-2-(AMINOALKYL- PHENYL)-5H-PYRAZ0L0 [1,5-C] [1,3] BENZ0XAZIN-5-YL) PHENYL METHANONE DERIVATIVES AS HIV VIRAL REPLIATION INHIBITORS

The present invention relates to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, a

Pyrazole derivatives

A compound of the formula (I): wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl, etc.; R3 is lower alkoxy, etc.; R4 is hydroxy, etc.; X is O, S, etc.; Y is CH or N; Z is lower alkylene or lower alkenylene; and m is 0 or 1; or salts thereof, which are useful as a medicament.

Synthesis and Physical Properties of Alkoxymethylene Substituted Phenyl Cyclohexanecarboxylates

The homologous series of 4-alkoxymethylene-substituted-phenyl 4'-alkylcyclohexanecarboxylates are prepared.And their transition temperatures, bulk viscosities and birefringences have been measured comparing with the series of 4-alkoxy-substituted-phenyl 4'-alkylcyclohexanecarboxylates.The differences between the alkoxymethylene-substituted series and alkoxy-substituted series are discussed.Alkoxymethylene groups contribute to lowering the transition temperatures, and also reducing the bulk viscosities and optical anisotropy compared to the alkoxy groups as terminal groups of mesogens.This is apparently due to the higher flexibility of the alkoxymethylene groups, which affected the packing of molecules.

HIGHLY SELECTIVE OXIDATION OF BENZYLIC ALCOHOLS WITH CETYLTRIMETHYLAMMONIUM PERMANGANATE

Cetyltrimethylammonium permanganate (CTAP) has been found to be a mild and highly selective reagent for the oxidation of benzylic alcohols to the corresponding aldehydes or ketones.