15818-31-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(3,3-dimethylbutyl)-1H-isoindole-1,3(2H)-dione is used as a therapeutic agent for the treatment of leprosy, multiple myeloma, and certain autoimmune diseases. Its immunomodulatory and anti-inflammatory properties contribute to its effectiveness in managing these conditions.
Used in Research and Drug Development:
2-(3,3-dimethylbutyl)-1H-isoindole-1,3(2H)-dione is utilized as a research compound for exploring its anti-angiogenic and anti-tumor properties. This investigation aims to understand its potential in the development of new treatments for various cancers and other related conditions.
Used in Anti-Angiogenic Applications:
2-(3,3-dimethylbutyl)-1H-isoindole-1,3(2H)-dione is employed as an anti-angiogenic agent, which inhibits the formation of new blood vessels in tumors, thereby limiting their growth and spread.
Used in Anti-Tumor Applications:
2-(3,3-dimethylbutyl)-1H-isoindole-1,3(2H)-dione is used as an anti-tumor agent, exhibiting potential in the treatment of various types of cancer by interfering with tumor growth and progression mechanisms.

Upstream product

• 20213-82-5 2-(3-methyl-but-3-enyl)-2,3-dihydro-1H-isoindole-1,3-dione 
• 74-88-4 methyl iodide 
• 524-38-9 N-hydroxyphthalimide 
• 558-37-2 tert-butylethylene 
• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 677-22-5 tert-butylmagnesium chloride 

Downstream Products

• 15673-00-4 3,3-dimethylbutylamine 

Relevant academic research and scientific papers

Intermolecular Radical Mediated Anti-Markovnikov Alkene Hydroamination Using N-Hydroxyphthalimide

An intermolecular anti-Markovnikov hydroamination of alkenes has been developed using triethyl phosphite and N-hydroxyphthalimide. The process tolerates a wide range of alkenes, including vinyl ethers, silanes, and sulfides as well as electronically unbiased terminal and internal alkenes. The resultant N-alkylphthalimides can readily be transformed to the corresponding primary amines. Mechanistic probes indicate that the process is mediated via a phosphite promoted radical deoxygenation of N-hydroxyphthalimide to access phthalimidyl radicals.

Hydroalkylation of Olefins to Form Quaternary Carbons

Metal-hydride hydrogen atom transfer (MHAT) functionalizes alkenes with predictable branched (Markovnikov) selectivity. The breadth of these transformations has been confined to π-radical traps; no sp3 electrophiles have been reported. Here we describe a Mn/Ni dual catalytic system that hydroalkylates unactivated olefins with unactivated alkyl halides, yielding aliphatic quaternary carbons.

Hydroalkylation of Olefins to Form Quaternary Carbons

Metal-hydride hydrogen atom transfer (MHAT) functionalizes alkenes with predictable branched (Markovnikov) selectivity. The breadth of these transformations has been confined to π-radical traps; no sp3 electrophiles have been reported. Here we describe a Mn/Ni dual catalytic system that hydroalkylates unactivated olefins with unactivated alkyl halides, yielding aliphatic quaternary carbons.

Copper nanoparticle-catalyzed cross-coupling of alkyl halides with Grignard reagents

A cross-coupling reaction between alkyl bromides and chlorides and various Grignard reagents was carried out in the presence of commercially available copper or copper oxide nanoparticles as a catalyst and an alkyne additive. The catalytic system shows high activity, a broad scope, and good functional group tolerance.