156741-98-9Relevant academic research and scientific papers
Templated hierarchical self-assembly of poly(p-aryltriazole) foldamers
Pfukwa, Rueben,Kouwer, Paul H. J.,Rowan, Alan E.,Klumperman, Bert
, p. 11040 - 11044 (2013)
A biomimetic approach has been used for the templated self-assembly of a helical poly(para-aryltriazole) foldamer. The solvophobic folding process yields helices that further self-assemble into long nanotubes (see picture; scale bar: 100a nm). Constructs of controlled length and chirality can be generated by applying a poly(γ-benzyl-l-glutamate) scaffold at the appropriate assembly conditions, mimicking tobacco mosaic virus self-assembly. Copyright
Telescoped synthesis of C3-functionalized (E)-arylamidines using Ugi-Mumm and regiospecific quinazolinone rearrangements
Jaffett, Victor A.,Nerurkar, Alok,Cao, Xufeng,Guzei, Ilia A.,Golden, Jennifer E.
supporting information, p. 3118 - 3128 (2019/03/26)
An efficient four-step, six-transformation protocol was developed to afford bioactive N-alkyl- or N-arylamide (E)-arylamidines featuring strategic amidine C3 modifications which were inaccessible or low yielding by previous methods. This synthetic approac
Benzodiazepines HDM2 inhibitor as well as preparation method and application thereof
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Paragraph 0056-0058, (2018/10/11)
The invention relates to a benzodiazepines compound, a preparation method of the benzodiazepines compound and medical application of the benzodiazepines compound, in particular to application of the benzodiazepines compound as a HDM2 inhibitor in treatmen
Synthesis of Diverse Nitrogen Heterocycles via Palladium-Catalyzed Tandem Azide–Isocyanide Cross-Coupling/Cyclization: Mechanistic Insight using Experimental and Theoretical Studies
Ansari, Arshad J.,Pathare, Ramdas S.,Maurya, Antim K.,Agnihotri, Vijai K.,Khan, Shahnawaz,Roy, Tapta Kanchan,Sawant, Devesh M.,Pardasani, Ram T.
supporting information, p. 290 - 297 (2017/12/07)
A rapid and elegant tandem azide–isocyanide cross-coupling/cyclization protocol has been developed based on a nitrene transfer reaction. The palladium-catalyzed ligand-free methodology led to the synthesis of three different heterocyclic scaffolds with excellent atom/step/redox economy. Studies based on first-principles-based quantum calculations and control experiments unraveled a concerted process of nitrene transfer reaction on isocyanides, ruling out the metallaaziridine intermediate reported earlier. This finding could pave the way for novel applications of nitrene transfer reactions to generate bioactive heterocycles. (Figure presented.).
A reliable one-pot synthesis of aryl azides from aryl amines using organotin azides as effective and recoverable reagents
Godoy Prieto, Leonela,Lo Fiego, Marcos J.,Chopa, Alicia B.,Lockhart, María T.
supporting information, p. 26 - 32 (2016/12/18)
A mild and mass-efficient procedure based on the one-pot diazotization-azidodediazoniation of aromatic amines is described. A wide range of aryl azides are obtained in moderate to high yields by using tributyltin azide as an effective and reusable azide source in the presence of p-toluenesulfonic acid at room temperature. The method was also successfully applied employing an insoluble polymer-supported organotin azide.
Synthesis of 2,1-benzisoxazole-3(1H)-ones by base-mediated photochemical N-O bond-forming cyclization of 2-azidobenzoic acids
Dzhons, Daria Yu.,Budruev, Andrei V.
supporting information, p. 874 - 881 (2016/07/06)
The base-mediated photochemical cyclization of 2-azidobenzoic acids with the formation of 2,1-benzisoxazole-3(1H)-ones is reported. The optimization and scope of this cyclization reaction is discussed. It is shown that an essential step of the ring closure of 2-azidobenzoic acids is the formation and photolysis of 2-azidobenzoate anions.
Efficient conversion of aromatic amines into azides: A one-pot synthesis of triazole linkages
Barral, Karine,Moorhouse, Adam D.,Moses, John E.
, p. 1809 - 1811 (2008/02/02)
An efficient and improved procedure for the preparation of aromatic azides and their application in the Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition ("click reaction") is described. The synthesis of aromatic azides from the corresponding amies i
Parallel fluorous biphasic synthesis of 3H-quinazolin-4-ones by an Aza-Wittig reaction employing perfluoroalkyl-tagged triphenylphosphine
Barthélémy, Sophie,Schneider, Siegfried,Bannwarth, Willi
, p. 807 - 810 (2007/10/03)
A perfluoroalkyl-tagged triphenylphosphine was applied in a fluorous biphasic system for the efficient parallel synthesis of 3H-quinazolin-4-ones via an Aza-Wittig reaction. The products were isolated by solid-phase extraction on fluorous reversed-phase silica gel. A new solid-phase bound phosphine derivative was used for comparison and yielded similar results.
A photoaffinity probe for 5-hydroxyeicosanoid dehydrogenase suitable for radioiodination
Kim, Seongjin,Adiyaman, Yurdanur,Saha, Goutam,Powell, William S.,Rokach, Joshua
, p. 4445 - 4448 (2007/10/03)
5-Hydroxy eicosanoid dehydrogenase (5h-dh) is a key enzyme responsible for the biosynthesis of 5-oxo-ETE, a potent eosinophil chemoattractant. To facilitate the identification and characterization of 5h-dh we have synthesized a photoaffinity ligand 7, des
Synthesis of a radioactive photoaffinity arachidonic acid analog
Perrier, Helene,Prasit, Petpiboon,Wang, Zhaoyin
, p. 1501 - 1502 (2007/10/02)
A novel photoaffinity probe based of arachidonic acid was synthesized by coupling 20-hydroxyarachidonic acid and 2-azido-5-iodobenzoic acid. The key epoxide required for the formation of 20-hydroxyarachidonic acid was obtained using a new mild and safe me
