185505-58-2Relevant academic research and scientific papers
FACTOR XA INHIBITORS
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Page/Page column 112, (2008/12/07)
The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat certain conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
Simplified cyclic analogues of bastadin-5. Structure-activity relationships for modulation of the RyR1/FKBP12 Ca2+ channel complex
Masuno, Makoto N.,Pessah, Isaac N.,Olmstead, Marilyn M.,Molinski, Tadeusz F.
, p. 4497 - 4511 (2007/10/03)
Bastadin-5, a brominated macrodilactam from the marine sponge Ianthella basta, enhances release of Ca2+ from stores within the sarcoplasmic reticulum (SR) of muscle and nonmuscle cells by modulating RyR1/FKBP12 complex. Analogues of bastadin-5
A photoaffinity probe for 5-hydroxyeicosanoid dehydrogenase suitable for radioiodination
Kim, Seongjin,Adiyaman, Yurdanur,Saha, Goutam,Powell, William S.,Rokach, Joshua
, p. 4445 - 4448 (2007/10/03)
5-Hydroxy eicosanoid dehydrogenase (5h-dh) is a key enzyme responsible for the biosynthesis of 5-oxo-ETE, a potent eosinophil chemoattractant. To facilitate the identification and characterization of 5h-dh we have synthesized a photoaffinity ligand 7, des
