156767-69-0

Basic information

• Product Name: 3beta-Hydroxyergost-5-en-7-one
• Synonyms: 3beta-Hydroxyergost-5-en-7-one;3β-Hydroxyergost-5-en-7-one
• CAS NO: 156767-69-0
• Molecular Formula: C28H46O2
• Molecular Weight: 415
• Mol File: 156767-69-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 508.979 °C at 760 mmHg
• Flash Point: 215.443 °C
• Appearance: /
• Density: 1.004 g/cm³
• CAS DataBase Reference: 3beta-Hydroxyergost-5-en-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3beta-Hydroxyergost-5-en-7-one(156767-69-0)
• EPA Substance Registry System: 3beta-Hydroxyergost-5-en-7-one(156767-69-0)

Safety Data

• Hazardous Substances Data: 156767-69-0(Hazardous Substances Data)

Usage

Uses

(24S)-3β-Hydroxyergost-5-en-7-one is a secondary metabolite found in the fruiting bodies of Cyttaria johowii. (24S)-3β-Hydroxyergost-5-en-7-one is a derivative of Ergosterol (E599240) which is the most important of the provitamins D. Ergosterol is usually obtained from yeast, synthesized from simple sugars such as glucose.

Upstream product

• 73746-20-0 (24R)-α-/(24S)-β-methylcholesterol acetate 
• 474-62-4 24-Methylcholesterol 
• 1900-53-4 24-methylcholest-5-en-3β-yl acetate 
• 4651-51-8 campesterol 
• 71486-03-8 ergost-5-en-7-on-3β-ol acetate 

Relevant articles and documents

Synthesis and assessment of the relative toxicity of the oxidised derivatives of campesterol and dihydrobrassicasterol in U937 and HepG2 cells

The cytotoxic effects of the oxidised derivatives of the phytosterols, stigmasterol and β-sitosterol, have previously been shown to be similar but less potent than those of the equivalent cholesterol oxides in the U937 cell line. The objective of the present study was to compare the cytotoxic effects of the oxidised derivatives of synthetic mixtures of campesterol and dihydrobrassicasterol in both the U937 and HepG2 cell lines. The parent compounds consisted of a campesterol: dihydrobrassicasterol mix at a ratio of 2:1 (2CMP:1DHB) and a dihydrobrassicasterol:campesterol mix at a ratio of 3:1 (3DHB:1CMP). The 2CMP:1DBH oxides were more cytotoxic in the U937 cells than the 3DBH:1CMP oxides but the difference in cytotoxicity was less marked in the HepG2 cells. The order of toxicity of the individual oxidation products was found to be similar to that previously observed for cholesterol, β-sitosterol and stigmasterol oxidation products in the U937 cell line. There was an increase in apoptotic nuclei in U937 cells incubated with the 7-keto and 7β-OH derivatives of both 2CMP:1DHB and 3DHB:1CMP and also in the presence of 3DHB:1CMP-3β,5α,6β-triol and 2CMP:1DHB-5β,6β-epoxide. An additional oxidation product synthesised from 2CMP:1DHB, 5,6,22,23-diepoxycampestane, was cytotoxic but did not induce apoptosis. These results signify the importance of campesterol oxides in the overall paradigm of phytosterol oxide cytotoxicity.