73746-20-0Relevant academic research and scientific papers
Oxidized derivatives of dihydrobrassicasterol: Cytotoxic and apoptotic potential in U937 and HepG2 cells
Kenny, Olivia,O'Callaghan, Yvonne,O'Connell, Niamh M.,McCarthy, Florence O.,Maguire, Anita R.,O'Brien, Nora M.
experimental part, p. 5952 - 5961 (2012/10/07)
The ability of phytosterol compounds to reduce plasma serum cholesterol levels in humans is well investigated. However, phytosterols are structurally similar to cholesterol with a double bond at the C5-6 position and are therefore susceptible to oxidation. Much research has been carried out on the biological effects of cholesterol oxidation products (COPs) in vitro. In contrast, there is less known about phytosterol oxidation products (POPs). From previous studies, it is apparent that oxidized derivatives of the phytosterols, β-sitosterol and stigmasterol, are cytotoxic in vitro but are less potent than their COP counterparts. In the present study, the cytotoxic and apoptotic potential of oxidized derivatives of dihydrobrassicasterol (DHB) including 5α,6α-epoxyergostan-3β-ol (α-epoxide), 5β,6β-epoxyergostan-3β-ol (β-epoxide), ergost-5-en-7-on- 3β-ol (7-keto), ergost-5-ene-3β,7β-diol (7-β-OH), and ergostane-3β,5α,6β-triol (triol) were evaluated in the U937 and HepG2 cell lines. In general, 7-keto, 7-β-OH, and triol derivatives had a significant cytotoxic impact on U937 and HepG2 cells. The oxides appear to be more toxic toward U937 cells. In line with previous findings, the POPs investigated in this study were less potent than the equivalent COPs. The results add to the body of data on the toxicity of individual POPs.
24β-METHYLCHOLESTA-5,22E,25-TRIEN-3β-OL AND 24α-ETHYL-5α-CHOLEST-22E-EN-3β-OL FROM CLERODENDRUM FRAGRANS
Akihisa, Toshihiro,Ghosh, Parthasarathi,Thakur, Swapnadip,Oshikiri, Satoshi,Tamura, Toshitake,Matsumoto, Taro
, p. 241 - 244 (2007/10/02)
Two minor sterols isolated from Clerodendrum fragrans were identified as 24β-methylcholesta-5,22E,25-trien-3β-ol and 24a-ethyl-5α-cholest-22E-en-3β-ol of which the former has so far been detected only in a marine sponge.The other sterols identified in the plant were clerosterol, 22E-dehydroclerosterol and several other common sterols.Key Word Index - Clerodendrum fragrans; Verbenaceae; sterol; 24β-methylcholesta-5,22E,25-trien-3β-ol; 24α-ethyl-5α-cholest-22E-en-3β-ol.
