156772-60-0

Basic information

• Product Name: 2,5-DIBROMO-3-FLUOROPYRIDINE
• Synonyms: 2,5-DIBROMO-3-FLUOROPYRIDINE
• CAS NO: 156772-60-0
• Molecular Formula: C₅H₂Br₂FN
• Molecular Weight: 254.88
• Product Categories: Pyridine;Halides;Heterocycles;Pyridines;Boronic Acid;pyridine series
• Mol File: 156772-60-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 215.9 °C at 760 mmHg
• Flash Point: 84.4 °C
• Appearance: White/Solid
• Density: 2.137 g/cm³
• Vapor Pressure: 0.212mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -3.99±0.20(Predicted)
• CAS DataBase Reference: 2,5-DIBROMO-3-FLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIBROMO-3-FLUOROPYRIDINE(156772-60-0)
• EPA Substance Registry System: 2,5-DIBROMO-3-FLUOROPYRIDINE(156772-60-0)

Safety Data

• RIDADR: UN2811
• HazardClass: 6.1
• Hazardous Substances Data: 156772-60-0(Hazardous Substances Data)

Usage

Uses

2,5-Dibromo-3-fluoropyridine can be used as PRC2 inhibitors to treat cancer.

InChI:InChI=1/C5H2Br2FN/c6-3-1-4(8)5(7)9-2-3/h1-2H

Upstream product

• 90902-84-4 2,5-dibromopyridin-3-ylamine 

Downstream Products

• 156772-62-2 5-bromo-3-fluoro-2-(4-octyloxyphenyl)pyridine 
• 1160936-52-6 1-(5-bromo-3-fluoropyridin-2-yl)ethan-1-one 
• 1162674-74-9 5-bromo-3-fluoro-2-methylpyridine 

Relevant articles and documents

Application of 1,1-ADEQUATE, HMBC, and Density Functional Theory to Determine Regioselectivity in the Halogenation of Pyridine N-Oxides

The 1,1-ADEQUATE spectrum clearly shows specific two-bond proton to carbon correlations to unequivocally distinguish the major and minor regioisomers of ortho-halogenated pyridines and to aid in assignment of the corresponding proton and carbon chemical shifts. M06-2X/6-31+G(d,p) free energies of the regioisomeric intermediates arising from deprotonation correctly predict the experimentally observed preference and thus can be used to tune the substituent pattern to yield a desired regiochemical outcome.

Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

Alkyne compounds having MCH-receptor antagonistic activity, which are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.

Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

The present invention relates to alkyne compounds of general formula I wherein the groups and radicals A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one alkyne according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.