1160936-52-6

Basic information

• Product Name: 1-(5-Bromo-3-fluoropyridin-2-yl)ethanone
• Synonyms: 1-(5-Bromo-3-fluoropyridin-2-yl)ethanone;Ethanone, 1-(5-bromo-3-fluoro-2-pyridinyl)-
• CAS NO: 1160936-52-6
• Molecular Formula: C₇H₅BrFNO
• Molecular Weight: 218.0231032
• Product Categories: Other Fluorinated Heterocycles;Pyridines;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Heterocyclic Fluorinated Building Blocks
• Mol File: 1160936-52-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 239.453 °C at 760 mmHg
• Flash Point: 98.618 °C
• Appearance: /
• Density: 1.62 g/cm³
• PKA: -1.82±0.10(Predicted)
• CAS DataBase Reference: 1-(5-Bromo-3-fluoropyridin-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-Bromo-3-fluoropyridin-2-yl)ethanone(1160936-52-6)
• EPA Substance Registry System: 1-(5-Bromo-3-fluoropyridin-2-yl)ethanone(1160936-52-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 1160936-52-6(Hazardous Substances Data)

Usage

General Description

1-(5-Bromo-3-fluoropyridin-2-yl)ethanone is a chemical compound with the molecular formula C8H6BrFNO. It is a yellow to brown solid that is commonly used in pharmaceutical and agrochemical research as a building block for the synthesis of various biologically active compounds. 1-(5-Bromo-3-fluoropyridin-2-yl)ethanone contains a pyridine ring with both bromine and fluorine substituents, as well as a ketone functional group attached to an ethanone chain. Its specific structure and reactivity make it a valuable intermediate for the development of new drugs and pesticides. Additionally, 1-(5-Bromo-3-fluoropyridin-2-yl)ethanone is also used in medicinal chemistry for the modification and optimization of bioactive molecules.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 886373-28-0 5-bromo-3-fluoropyridine-2-carbonitrile 
• 156772-60-0 2,5-dibromo-3-fluoropyridine 
• 127-19-5 N,N-dimethyl acetamide 
• 75-16-1 methylmagnesium bromide 
• 676-58-4 methylmagnesium chloride 
• 573675-25-9 5-bromo-3-nitropyridine-2-carbonitrile 
• 1357259-48-3 C₆H₂BrFN₂*ClH 

Downstream Products

• 1357259-49-4 C₁₆H₁₇BrN₂O₃ 
• 1357259-53-0 C₄₂H₄₂N₆O₅ 
• 1357259-51-8 C₂₀H₂₀BrN₃O₄ 
• 1357259-50-7 1-(3-amino-5-bromopyridin-2-yl)ethan-1-one 

Relevant articles and documents

PLASMA KALLIKREIN INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.

COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE

The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), Formula (II), or Formula (III), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.