1569-08-0

Basic information

• Product Name: 2-BENZYL-4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOLE
• Synonyms: 2-BENZYL-4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOLE;2-benzyl-4,4-dimethyl-2-oxazoline;4,4-dimethyl-2-(phenylmethyl)-4,5-dihydrooxazole;4,5-dihydro-4,4-dimethyl-2-(phenylmethyl)-oxazol;2-(benzyl)-4,4-dimethyl-5H-oxazole;4,4-dimethyl-2-(phenylmethyl)-5H-1,3-oxazole;2-benzyl-4,4-dimethyl-4,5-dihydrooxazole
• CAS NO: 1569-08-0
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.25
• Mol File: 1569-08-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 270.2°Cat760mmHg
• Flash Point: 89.3°C
• Appearance: /
• Density: 1.03g/cm³
• Vapor Pressure: 0.0115mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-BENZYL-4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOLE(1569-08-0)
• EPA Substance Registry System: 2-BENZYL-4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOLE(1569-08-0)

Safety Data

• Statements: 36
• Safety Statements: 24/25-26
• RTECS: RP6798960
• Hazardous Substances Data: 1569-08-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 22, p. 4471, 1981 DOI: 10.1016/S0040-4039(01)93017-5

InChI:InChI=1/C12H15NO/c1-12(2)9-14-11(13-12)8-10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3

Upstream product

• 103-82-2 phenylacetic acid 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 1772-43-6 2,4,4-trimethyl oxazoline 
• 108-86-1 bromobenzene 
• 591-50-4 iodobenzene 
• 140-29-4 phenylacetonitrile 
• 101-97-3 Ethyl 2-phenylethanoate 
• 100-44-7 benzyl chloride 
• 118559-32-3 4,4-dimethyl-2-(tri-n-butylstannyl)-2-oxazoline 
• 53244-68-1 2-(methylthio)-4,4-dimethyl-4,5-dihydro-1,3-oxazole 
• 6921-34-2 benzylmagnesium chloride 
• 51677-11-3 phenyl-acetic acid-(2-chloro-1,1-dimethyl-ethylamide) 

Downstream Products

• 926647-29-2 2-[2-(2-bromophenyl)-1-phenylethyl]-4,4-dimethyl-2-oxazoline 
• 926647-40-7 C₂₃H₂₉NO 
• 1258964-47-4 (Me2N)3Ti(η-N-(4,4-dimethyl-(2-CHPh)oxazoline)) 
• 59412-07-6 7-chloro-3-phenylquinolin-2(1H)-one 
• 106059-32-9 Phenyl-acetic acid 2-[3-(4-bromo-phenyl)-thioureido]-2-methyl-propyl ester 
• 108086-19-7 2-(α-bromo-α-nitrobenzyl)-4,4-dimethyl-2-oxazoline 
• 108086-20-0 2-(α-chloro-α-nitrobenzyl)-4,4-dimethyl-2-oxazoline 
• 492-38-6 2-phenylacrylic acid 
• 868069-26-5 2-[3-(2-chlorophenyl)-1-phenylpropyl]-4,4-dimethyl-2-oxazoline 
• 868069-31-2 2-[3-(2-bromophenyl)-1-phenylbutyl]-4,4-dimethyl-2-oxazoline 
• 868069-27-6 2-[3-(2-bromophenyl)-1-phenylpropyl]-4,4-dimethyl-2-oxazoline 
• 98-10-2 benzenesulfonamide 
• 104127-52-8 6-(methoxy,methyl)-5-benzyl-3,3-dimethyl-7-oxo-4-oxa-1-azabicyclo<3.2.0>heptane 
• 108086-12-0 2-Benzhydryl-4,4-dimethyl-4,5-dihydro-oxazole 

Relevant articles and documents

Reactions of 2-(Tributylstannyl)-4,4-dimethyl-2-oxazoline with Organic Halides. Unusual Product from Aroyl Halide

2-(Tributylstannyl)-4,4-dimethyl-2-oxazoline (1) reacted with aroyl chloride smoothly without any palladium catalyst to give the unusual product, bis(N-aroyl-4,4-dimethyl-2-oxazolinylidene) in good yields.The reaction of 1 with other types of halide neede

Hexaalkylguanidinium salts as ionic liquids - Applications in titanium and aluminium alcoholate assisted synthesis

The solubility of titanium and aluminium alcoholates and of titanium tetrakis(trimethylsilanolate) in several hexaalkylguanidinium-based room temperature ionic liquids was screened. The solvent/solute combinations which displayed the highest alcoholate solubility and stability were applied as Lewis-acidic catalytic media for several dehydrating cyclocondensations: lactamisation of ω-aminocarboxylic acids, direct amidation of carboxylic acids, synthesis of oxazolines from carboxylic acids and 2-aminoethanol, lactonisation of 6-hydroxyhexanoic acid, and Paal-Knorr synthesis of pyrroles.

Aryl-oxazoline chelates of first-row transition metals: Structures of {Κ-C,N-(o-C6H4)CMe2(COCH 2CMe2N)}FeCl(py) and [(Κ-C,N-(o-C6H 4)CMe2(COCH2CMe2N)}Cr(μ-Cl)] 2

Aryl-oxazoline synthons have been explored for the preparation of strong-field first-row transition metal chelate species. With 4,4-dimethyl-2-phenyloxazoline (HPhOx), no CH bond activations afforded complexation, and aside from Zn(Κ-C,N-4,4-Me2-2-(o-C 6H4)oxazoline)2 (Zn(PhOx)2), aryl-coupling reactions were noted with 4,4-dimethyl-2-(2-lithiophenyl)oxazoline (LiPhOx) and MX2; [Κ-N,N-{4,4-Me2-(2-o-C 6H4)-2-oxazoline}2]CoCl2 (1-Co) was structurally characterized. Metalations with 4,4-dimethyl-2-benzyloxazoline (PhCH2Ox) were prone to deprotonation, as exemplified by (Me 2N)3Ti(η-N-(4,4-dimethyl-(2-CHPh)oxazoline)) (2) and bis-N,N′-(4,4-dimethyl-(2-pyridylmethylyl)oxazoline)Fe (3). Oxidative addition of 4,4-dimethyl-2-(2-bromophenylpropan-2-yl)oxazoline (BrPhCMe 2Ox) to Ni(COD)2 provided [{Κ-C,N-(o-C 6H4)CMe2(COCH2CMe 2N)}Ni]2(μ-Br)2 (42). With 4,4-dimethyl-2-(2-lithiophenylpropan-2-yl)oxazoline (LiPhCMe2Ox), salt (FeBr2) metathesis proved uncompetitive with oxazoline ring-opening, as exhibited by [{Κ-N,O-C6H4CMe 2C=NCMe2CH2(μ-O)-}BrFe{Κ-N,O-C 6H4CMe2C=NCMe2CH2(μ-O) -}FeBr]Li {Κ-N,O-C6H4CMe2-C=NCMe 2CH2(μ-O)-}(DME) (5-Fe2Li). Metatheses utilizing (PhCMe2Ox)2Zn, prepared from LiPhCMe 2Ox and ZnCl2, gave structurally characterized dichromium, i.e., [{Κ-C,N-(o-C6H4)CMe2 (COCH 2CMe2N)}Cr]2(μ-Cl)2 (6 2), and iron, i.e., {Κ-C,N-{(o-C6H 4)CMe2(COCH2CMe2N)}Fe(py)Cl (7) products. Bis-aryloxazoline metal complexes proved difficult to prepare, with {Κ-C,N-(o-C6H4)CMe2(COCH 2CMe2N)}2M (M = Ni, 9) the only clear example, although NMR evidence exists for M = Fe (8).