1569-17-1

Basic information

• Product Name: 4-METHYL-1,8-NAPHTHYRIDINE
• Synonyms: 4-METHYL-1,8-NAPHTHYRIDINE
• CAS NO: 1569-17-1
• Molecular Formula: C₉H₈N₂
• Molecular Weight: 144.17
• Mol File: 1569-17-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 271℃
• Flash Point: 116℃
• Appearance: /
• Density: 1.141
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.48±0.30(Predicted)
• CAS DataBase Reference: 4-METHYL-1,8-NAPHTHYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-1,8-NAPHTHYRIDINE(1569-17-1)
• EPA Substance Registry System: 4-METHYL-1,8-NAPHTHYRIDINE(1569-17-1)

Safety Data

• Hazardous Substances Data: 1569-17-1(Hazardous Substances Data)

Usage

Uses

4-Methyl-1,8-naphthyridine is used in the synthesis of azetidinyl ketolides for treatment of susceptible and multidrug resistant respiratory tract infections.

Upstream product

• 2802-08-6 (E)-4-(dimethylamino)but-3-en-2-one 
• 86847-59-8 2-(pivaloylamino)pyridine 
• 695-34-1 2-Amino-4-methylpyridine 
• 56-81-5 glycerol 
• 107-02-8 acrolein 
• 7668-02-2 4-methyl-1H,8H-[1,8]naphthyridine-2,7-dione 
• 51731-17-0 trans-4-methoxy-3-buten-2-one 
• 927-63-9 (E)-3-(dimethylamino)acrolein 
• 86847-77-0 2,2-Dimethyl-N-(4-methyl-2-pyridinyl)propanamide 
• 58035-56-6 2,7-dichloro-5-methyl-1,8-naphtyridine 

Downstream Products

• 129919-42-2 1a,1b,2,7b-tetrahydro-7-methyl-1,2-bis(phenylsulfonyl)-1H-azirino<1.2-a>cyclopropa<1.8>naphthyridine 
• 64379-46-0 1,8-naphthyridine-4-carboxaldehyde 

Relevant articles and documents

Method for preparing 1,8-naphthyridine and derivatives

The invention provides a method for preparing 1,8-naphthyridine and derivatives. The method comprises the following steps of adding an oxidizing agent and a compound in formula (I) or salt thereof into acid, so as to obtain a reaction liquid; stirring and heating the reaction liquid, uniformly dripping a compound in formula (II) to react, cooling to the room temperature, neutralizing by an alkaline solution, and extracting a water phase by solvent, so as to obtain an organic phase; concentrating the organic phase under reduced pressure, and removing the solvent, so as to obtain a compound in formula (III). The method overcomes the defects of low yield and high cost when the 1,8-naphthyridine and derivatives are synthesized by a Skraup method.

A one-pot method for the synthesis of naphthyridines via modified friedl?nder reaction

A one-pot method for the preparation of 1,8-naphthyridine derivatives is reported. The method involves the dimetalation of an appropriate N-2-pyridylpivalamide or tert-butylcarbamate followed by reaction with a β-dimethylamino or β-alkoxyacrolein derivative. This method is also applicable to 1,6-naphthyridines. Georg Thieme Verlag Stuttgart.