1569-17-1

Basic information

• Product Name: 4-METHYL-1,8-NAPHTHYRIDINE
• Synonyms: 4-METHYL-1,8-NAPHTHYRIDINE
• CAS NO: 1569-17-1
• Molecular Formula: C₉H₈N₂
• Molecular Weight: 144.17
• Mol File: 1569-17-1.mol

Chemical Properties

• Boiling Point: 271℃
• Flash Point: 116℃
• Appearance: /
• Density: 1.141
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.48±0.30(Predicted)
• CAS DataBase Reference: 4-METHYL-1,8-NAPHTHYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-1,8-NAPHTHYRIDINE(1569-17-1)
• EPA Substance Registry System: 4-METHYL-1,8-NAPHTHYRIDINE(1569-17-1)

Safety Data

• Hazardous Substances Data: 1569-17-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-METHYL-1,8-NAPHTHYRIDINE is used as a synthetic intermediate for the development of azetidinyl ketolides. These are a class of antibiotics designed to treat both susceptible and multidrug-resistant respiratory tract infections. The compound plays a crucial role in the synthesis process, contributing to the overall effectiveness of the final product.

Upstream product

• 58035-56-6 2,7-dichloro-5-methyl-1,8-naphtyridine 
• 2802-08-6 (E)-4-(dimethylamino)but-3-en-2-one 
• 86847-59-8 2-(pivaloylamino)pyridine 
• 695-34-1 2-Amino-4-methylpyridine 
• 107-02-8 acrolein 
• 51731-17-0 trans-4-methoxy-3-buten-2-one 
• 927-63-9 (E)-3-(dimethylamino)acrolein 
• 86847-77-0 2,2-Dimethyl-N-(4-methyl-2-pyridinyl)propanamide 
• 56-81-5 glycerol 
• 7668-02-2 4-methyl-1H,8H-[1,8]naphthyridine-2,7-dione 

Downstream Products

• 64379-46-0 1,8-naphthyridine-4-carboxaldehyde 
• 129919-42-2 1a,1b,2,7b-tetrahydro-7-methyl-1,2-bis(phenylsulfonyl)-1H-azirino<1.2-a>cyclopropa<1.8>naphthyridine 

Relevant articles and documents

Method for preparing 1,8-naphthyridine and derivatives

The invention provides a method for preparing 1,8-naphthyridine and derivatives. The method comprises the following steps of adding an oxidizing agent and a compound in formula (I) or salt thereof into acid, so as to obtain a reaction liquid; stirring and heating the reaction liquid, uniformly dripping a compound in formula (II) to react, cooling to the room temperature, neutralizing by an alkaline solution, and extracting a water phase by solvent, so as to obtain an organic phase; concentrating the organic phase under reduced pressure, and removing the solvent, so as to obtain a compound in formula (III). The method overcomes the defects of low yield and high cost when the 1,8-naphthyridine and derivatives are synthesized by a Skraup method.

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections

Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious safe

A one-pot method for the synthesis of naphthyridines via modified friedl?nder reaction

A one-pot method for the preparation of 1,8-naphthyridine derivatives is reported. The method involves the dimetalation of an appropriate N-2-pyridylpivalamide or tert-butylcarbamate followed by reaction with a β-dimethylamino or β-alkoxyacrolein derivative. This method is also applicable to 1,6-naphthyridines. Georg Thieme Verlag Stuttgart.