1569294-12-7

Basic information

• Product Name: N-(2-(N,N-diethylamino)ethyl)-6-(5-(2-iodophenoxy)pentanamido)quinoxaline-2-carboxamide
• Synonyms: N-(2-(N,N-diethylamino)ethyl)-6-(5-(2-iodophenoxy)pentanamido)quinoxaline-2-carboxamide
• CAS NO: 1569294-12-7
• Molecular Weight: 589.476
• Mol File: 1569294-12-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-(N,N-diethylamino)ethyl)-6-(5-(2-iodophenoxy)pentanamido)quinoxaline-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(N,N-diethylamino)ethyl)-6-(5-(2-iodophenoxy)pentanamido)quinoxaline-2-carboxamide(1569294-12-7)
• EPA Substance Registry System: N-(2-(N,N-diethylamino)ethyl)-6-(5-(2-iodophenoxy)pentanamido)quinoxaline-2-carboxamide(1569294-12-7)

Safety Data

• Hazardous Substances Data: 1569294-12-7(Hazardous Substances Data)

Upstream product

• 132902-33-1 ethyl 5-(2-iodophenoxy)pentanoic acid 
• 1155918-73-2 5-(2-iodophenoxy)pentanoic acid 
• 1569294-05-8 C₁₅H₂₁N₅O 
• 1119-46-6 5-chloro-valeric acid 
• 2323-81-1 ethyl 5-chloropentanoate 

Downstream Products

• 1569294-19-4 C₂₆H₃₂⁽¹²⁵⁾IN₅O₃ 

Relevant articles and documents

Synthesis and biological evaluation of new quinoxaline derivatives of ICF01012 as melanoma-targeting probes

The aim of this study was the synthesis and pharmacokinetic selection of a best melanin-targeting ligand for addressing anticancer agents to pigmented melanoma. Seven quinoxaline carboxamide derivatives were synthesized and radiolabeled with iodine-125. Biodistribution studies of compounds [ 125I]1a-g performed in melanoma-bearing mice tumor showed significant tumor uptake (range 2.43-5.68%ID/g) within 1 h after i.v. injection. Fast clearance of the radioactivity from the nontarget organs mainly via the urinary system gave high tumor-to-blood and tumor-to-muscle ratios. Given its favorable clearance and high tumor-melanoma uptake at 72 h, amide 1d was the most promising melanoma-targeting ligand in this series. Compound 1d will be used as building block for the design of new melanoma-selective drug delivery systems.