132902-33-1Relevant academic research and scientific papers
Alkylation-Terminated Catellani Reactions Using Alkyl Carbagermatranes
Jiang, Wei-Tao,Xiao, Bin,Xie, Xiu-Ying,Xu, Meng-Yu,Yang, Shuo
supporting information, p. 20450 - 20454 (2020/09/07)
The Catellani reaction has received substantial attention because it enables rapid multiple derivatization on aromatics. While using alkyl electrophiles to achieve ortho-alkylation was one of the earliest applications of the Catellani reaction, ipso-alkyl
Synthesis and biological evaluation of new quinoxaline derivatives of ICF01012 as melanoma-targeting probes
El Aissi, Radhia,Liu, Jianrong,Besse, Sophie,Canitrot, Damien,Chavignon, Olivier,Chezal, Jean-Michel,Miot-Noirault, Elisabeth,Moreau, Emmanuel
supporting information, p. 468 - 473 (2014/06/09)
The aim of this study was the synthesis and pharmacokinetic selection of a best melanin-targeting ligand for addressing anticancer agents to pigmented melanoma. Seven quinoxaline carboxamide derivatives were synthesized and radiolabeled with iodine-125. Biodistribution studies of compounds [ 125I]1a-g performed in melanoma-bearing mice tumor showed significant tumor uptake (range 2.43-5.68%ID/g) within 1 h after i.v. injection. Fast clearance of the radioactivity from the nontarget organs mainly via the urinary system gave high tumor-to-blood and tumor-to-muscle ratios. Given its favorable clearance and high tumor-melanoma uptake at 72 h, amide 1d was the most promising melanoma-targeting ligand in this series. Compound 1d will be used as building block for the design of new melanoma-selective drug delivery systems.
Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents
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, (2008/06/13)
The invention relates to leukotriene-B4 derivatives of formula I, STR1 in which n=1-10, R1 means radical CH2 OH, radical COOR4, radical CONHR5 or radical CONR6 R7, A means a cis,
