1570134-63-2Relevant academic research and scientific papers
Amide-Oxazoline Directed ortho-C–H Nitration Mediated by CuII
Gao, Tian-Hong,Wang, Chun-Meng,Tang, Kai-Xiang,Xu, Yun-Gen,Sun, Li-Ping
, p. 3005 - 3011 (2019)
A CuII-mediated ortho-C–H nitration using amide-oxazoline as the directing group has been developed. The reactions utilize sodium nitrite as the source of the nitro group under O2 atmosphere and proceed smoothly. The desired products can be obtained in yields of 26–94 %.
Cu(II)-catalyzed coupling of aromatic C-H bonds with malonates
Wang, Hong-Li,Shang, Ming,Sun, Shang-Zheng,Zhou, Zeng-Le,Laforteza, Brian N.,Dai, Hui-Xiong,Yu, Jin-Quan
, p. 1228 - 1231 (2015/03/14)
A new Cu(II)-catalyzed oxidative coupling of arenes with malonates has been developed using an amide-oxazoline directing group. The reaction proceeds via C(sp2)-H activation and malonate coupling, followed by intramolecular oxidative N-C bond formation. A variety of arenes bearing different substituents are shown to be compatible with this reaction.
Cu(II)-mediated C-H amidation and amination of arenes: Exceptional compatibility with heterocycles
Shang, Ming,Sun, Shang-Zheng,Dai, Hui-Xiong,Yu, Jin-Quan
supporting information, p. 3354 - 3357 (2014/03/21)
A Cu(OAc)2-mediated C-H amidation and amination of arenes and heteroarenes has been developed using a readily removable directing group. A wide range of sulfonamides, amides, and anilines function as amine donors in this reaction. Heterocycles present in both reactants are tolerated, making this a broadly applicable method for the synthesis of a family of inhibitors including 2-benzamidobenzoic acids and N-phenylaminobenzoates.
