1570135-71-5

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 3222-56-8 2-methylnicotinic acid 
• 3416-93-1 2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline 

Downstream Products

• 1570135-83-9 N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-methyl-4-(4-methylphenylsulfonamido)nicotinamide 

Relevant academic research and scientific papers

Cu(II)-mediated ortho C-H alkynylation of (hetero)arenes with terminal alkynes

Cu(II)-promoted ortho alkynylation of arenes and heteroarenes with terminal alkynes has been developed to prepare aryl alkynes. A variety of arenes and terminal alkynes bearing different substituents are compatible with this reaction, thus providing an alternative disconnection to Sonogashira coupling.

Cu(II)-mediated C-H amidation and amination of arenes: Exceptional compatibility with heterocycles

A Cu(OAc)2-mediated C-H amidation and amination of arenes and heteroarenes has been developed using a readily removable directing group. A wide range of sulfonamides, amides, and anilines function as amine donors in this reaction. Heterocycles present in both reactants are tolerated, making this a broadly applicable method for the synthesis of a family of inhibitors including 2-benzamidobenzoic acids and N-phenylaminobenzoates.