1570232-59-5

Basic information

• Product Name: tert-butyl N-{[4-(1-hydroxy-1-phenylethyl)pyridin-3-yl]methyl}carbamate
• Synonyms: tert-butyl N-{[4-(1-hydroxy-1-phenylethyl)pyridin-3-yl]methyl}carbamate
• CAS NO: 1570232-59-5
• Molecular Weight: 328.411
• Mol File: 1570232-59-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl N-{[4-(1-hydroxy-1-phenylethyl)pyridin-3-yl]methyl}carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-{[4-(1-hydroxy-1-phenylethyl)pyridin-3-yl]methyl}carbamate(1570232-59-5)
• EPA Substance Registry System: tert-butyl N-{[4-(1-hydroxy-1-phenylethyl)pyridin-3-yl]methyl}carbamate(1570232-59-5)

Safety Data

• Hazardous Substances Data: 1570232-59-5(Hazardous Substances Data)

Upstream product

• 3731-52-0 3-Aminomethylpyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 102297-41-6 3-<amino>methyl>pyridine 
• 98-86-2 acetophenone 

Relevant articles and documents

Control of site of lithiation of 3-(Aminomethyl)pyridine derivatives

Lithiation of N-(pyridin-3-ylmethyl)pivalamide, tert-butyl N-(pyridin-3-ylmethyl)carbamate, and N,N-dimethyl-N′-(pyridin-3-ylmethyl) urea with tert-butyllithium (3 equiv) in anhydrous tetrahydrofuran at -78 °C takes place on the nitrogen and on the ring at the 4-position. The dilithium reagents thus obtained react with various electrophiles to give the corresponding substituted derivatives in high yields. On the other hand, regioselective side-chain lithiation occurs with lithium diisopropylamide (3.3 equiv) at -20 to 0 °C. A mixture of ring and side-chain substitution products is obtained with n-butyllithium as the lithium reagent. Treatment of one of the ring-substituted products with trifluoroacetic anhydride in dichloromethane under reflux conditions led to formation of the corresponding 1H-pyrrolo[3,4-c]pyridine in high yield. Georg Thieme Verlag Stuttgart . New York.