157048-15-2Relevant academic research and scientific papers
Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives
Barth, Martine M.,Binet, Jean L.,Thomas, Didier M.,De Fornel, Daniel C.,Samreth, Soth,Schuber, Francis J.,Renaut, Patrice P.
, p. 2302 - 2312 (2007/10/03)
2,3-Oxidosqualene lanosterol-cyclase (OSC; EC 5.4.99.7) is an attractive target for the design of compounds that block hepatic cholesterol biosynthesis. (4aα,5α,6β,8aβ)-Decahydro-5,8a-dimethyl-2-(1,5,9- trimethyldecyl)-6-isoquinolinol (1) and simplified a
1,2,3,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-(8aβ)-6-isoquinolineamine derivatives, preparation method therefor and therapeutical use thereof
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, (2008/06/13)
1,2,3,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-(8aβ)-isoquinolineamines of formula (I), wherein groups R1 -R3 are as defined in the description, a method for preparing same, and therapeutical uses thereof as agents for inhibiting the biosynthesis of cholesterol, particularly epoxysqualene cyclase, which are useful as cholesterol and lipid lowering drugs, antiatheromatic and antifungal agents.
