15707-32-1Relevant academic research and scientific papers
Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones
Valderrama, Jaime A.,Leiva, Hilda,Rodriguez, Jaime A.,Theoduloz, Cristina,Schmeda-Hirshmann, Guillermo
, p. 3687 - 3693 (2008/12/21)
A series of naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups have been prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. The members of these series were tested on normal human fibroblasts and on a panel of four human cancer cell lines. Antitumor activities, which were in the range of IC50 1.3-89.5 μM, discussed in terms of LUMO energy, lipophilicity and size of the polyoxyethylene moiety.
Synthesis and antiplatelet, antiinflammatory and antiallergic activities of 2,3-disubstituted 1,4-naphthoquinones
Lien, Jin-Cherng,Huang, Li-Jiau,Wang, Jih-Pyang,Teng, Che-Ming,Lee, Kuo-Hsiung,Kuo, Sheng-Chu
, p. 1181 - 1187 (2007/10/03)
Modification of 2-acetamido-3-chloro-1,4-naphthoquinone, which has potent antiplatelet, antiallergic and antiinflammatory activities, led to a series of 2,3-disubstituted 1,4-naphthoquinones. Some of these compounds showed significant antiplatelet, antiallergic and antiinflammatory activities. Among them, 2-methoxy-3-chloro-1,4-naphthoquinone (15) and 2- ethoxy-3-chloro-1,4-naphthoquinone (17) exhibited potent inhibitory effects on neutrophil and mast cell degranulation. 2-Methoxy-1,4-naphthoquinone (20) and 2-ethoxy-1,4-naphthoquinone (21) exhibited potent inhibitory effect on neutrophil superoxide formation. These four compounds were thus selected for further evaluation.
