1571059-44-3

Upstream product

• 1292297-90-5 (S)-2-{3-[(4-methoxybenzyl)oxy]propyl}oxirane 
• 2181-42-2 trimethylsulphonium iodide 
• 1586033-45-5 (S)-6-(4-methoxybenzyloxy)hex-1-en-3-yl acetate 
• 154476-70-7 6-(4-methoxybenzyloxy)hex-1-en-3-ol 
• 119649-27-3 4-((4-methoxybenzyl)oxy)butanal 
• 119649-45-5 4-(p-methoxybenzyloxy)butan-1-ol 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 1586033-54-6 tert-butyl((R)-1-((4S,5S)-5-((S,E)-6-(4-methoxybenzyloxy)-3-(methoxymethoxy)hex-1-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)octyloxy)diphenylsilane 
• 1586033-62-6 tert-butyl-((R)-1-((4S,5S)-5-((S,Z)-6-(4-methoxybenzyloxy)-3-(methoxymethoxy)hex-1-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)octyloxy)diphenylsilane 
• 1586033-53-5 (S,E)-1-((4S,5S)-5-((R)-1-(tert-butyldiphenylsilyloxy)octyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-6-(4-methoxybenzyloxy)hex-1-en-3-ol 
• 1586033-64-8 (S,Z)-1-((4S,5S)-5-((R)-1-(tert-butyldiphenylsilyloxy)octyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-6-(4-methoxybenzyloxy)hex-1-en-3-ol 
• 1349725-50-3 C₂₀H₃₄O₃Si 
• 1586033-46-6 (S)-1-methoxy-4-((4-(methoxymethoxy)hex-5-enyloxy)methyl)benzene 

Relevant academic research and scientific papers

A Carbohydrate-based approach for the total synthesis of xyolide

We have achieved a total synthesis of xyolide, a bioactive nonenolide, by following a carbohydrate-based approach starting from d-(-)-ribose. The key reactions involved epoxide opening with a long-chain aliphatic Grignard reagent, Yamaguchi esterification

Asymmetric synthesis of naturally occurring nonenolide xyolide through cross metathesis and macrolactonization reaction

Asymmetric total synthesis of xyolide, a small ring macrolide is presented in this article. The synthesis is achieved through an 'E' selective cross metathesis (CM) reaction between two appropriate fragments followed by lactonization by Shiina method. One of the fragments containing 7S,8S,9R stereocenters of xyolide is accessed from n-nonanal by adopting an organocatalytic asymmetric α-aminooxylation, Z-selective Ando olefination, and substrate directed dihydroxylation reaction. The other fragments containing 4S stereocenter was prepared by ME-DKR (metal enzyme combined dynamic kinetic resolution) method.