1571082-52-4Relevant academic research and scientific papers
Enantioselective Lewis base catalyzed phosphonyldifluoromethylation of allylic fluorides using a: C -silyl latent pronucleophile
Zi, You,Lange, Markus,Vilotijevic, Ivan
, p. 5689 - 5692 (2020)
The first enantioselective phosphonyldifluoromethylation is enabled by the use of diethyl (difluoro(trimethylsilyl)-methyl)phosphonate reagent as a latent pronucleophile in the Lewis base catalyzed substitution of allylic fluorides. The reaction proceeds
Synthesis of Morita–Baylis–Hillman-fluorides using 1,1,2,2-tetrafluoroethyl-N,N-dimethylamine
Sumii, Yuji,Nagasaka, Takato,Matsuno, Ayaka,Hayashi, Hidetoshi,Mimura, Hideyuki,Kagawa, Takumi,Shibata, Norio
, (2021/08/18)
Morita–Baylis–Hillman (MBH)-fluorides are valuable platforms for asymmetric allylic substitution reactions. However, the preparation of MBH-fluorides requires the use of an explosive fluorinating reagent, namely (diethylamino)sulfur trifluoride (DAST). Th
Enantioselective Trichloromethylation of MBH-Fluorides with Chloroform Based on Silicon-assisted C-F Activation and Carbanion Exchange Induced by a Ruppert-Prakash Reagent
Nishimine, Takayuki,Taira, Hiromi,Tokunaga, Etsuko,Shiro, Motoo,Shibata, Norio
supporting information, p. 359 - 363 (2016/01/25)
Enantioselective trichloromethylation of Morita-Baylis-Hillman (MBH)-type allylic fluorides with chloroform (HCCl3) under organocatalysis was achieved with high to excellent enantioselectivities. Silicon-assisted C-F bond activation by a Rupper
Kinetic resolution of allyl fluorides by enantioselective allylic trifluoromethylation based on silicon-assisted c-F bond cleavage
Nishimine, Takayuki,Fukushi, Kazunobu,Shibata, Naoyuki,Taira, Hiromi,Tokunaga, Etsuko,Yamano, Akihito,Shiro, Motoo,Shibata, Norio
supporting information, p. 517 - 520 (2014/01/23)
Two birds, one stone! The first kinetic resolution of allyl fluorides was achieved by the development of an organocatalyzed enantioselective allylic trifluoromethylation. Two kinds of chiral fluorinated compounds, which incorporate C-F and C-CF3 units, respectively, can thus be accessed by a single transformation.
