1571111-33-5

Basic information

• Product Name: N-phenyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide
• Synonyms: N-phenyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide
• CAS NO: 1571111-33-5
• Molecular Weight: 380.251
• Mol File: 1571111-33-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-phenyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide(1571111-33-5)
• EPA Substance Registry System: N-phenyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide(1571111-33-5)

Safety Data

• Hazardous Substances Data: 1571111-33-5(Hazardous Substances Data)

Upstream product

• 105679-22-9 7-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine 
• 321436-06-0 7-bromo-3,4-dihydro-2H-1,4-benzoxazin-3-one 
• 38191-34-3 2-amino-5-bromophenol 
• 27684-84-0 5-bromo-2-nitrophenol 
• 1361110-64-6 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 1571111-32-4 7-(3-amino-1H-indazol-4-yl)-N-phenyl-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide 

Relevant articles and documents

Discovery of a new series of naphthamides as potent VEGFR-2 kinase inhibitors

Inhibition of VEGFR-2 signaling pathway has already become one of the most promising approaches for the treatment of cancer. In this study, we describe the design, synthesis, and biological evaluation of a new series of naphthamides as potent inhibitors of VEGFR-2. Among these compounds, 14c exhibited high VEGFR-2 inhibitory potency in both enzymatic and HUVEC cellular proliferation assays, with IC50 values of 1.5 and 0.9 nM, respectively. Kinase selectivity profiling revealed that 14c was a multitargeted inhibitor, and it also exhibited good potency against VEGFR-1, PDGFR-β, and RET. Furthermore, 14c effectively blocked tube formation of HUVEC at nanomolar level. Overall, 14c might be a promising candidate for the treatment of cancer.