157128-91-1

Usage

Derivative of isoindole-1,3-dione

The compound is based on the core structure of isoindole-1,3-dione, with additional functional groups or substituents attached to it.

2-[(3-methyl-2-butenyl)oxy] substituent

A 3-methyl-2-butenyl group is attached to an oxygen atom, which is further connected to the isoindole-1,3-dione core structure through an ether linkage (-O-).

Chemical and pharmaceutical applications

The compound is used in various chemical reactions and processes, as well as in the synthesis of pharmaceutical compounds.

Building block in organic synthesis

The compound serves as a starting material or intermediate in the synthesis of more complex organic molecules.

Potential precursor for the synthesis of biologically active molecules

The compound may be used as a starting point for the synthesis of molecules with biological activity, which could have therapeutic or diagnostic applications.

Suitability for use in medicinal chemistry and drug development

The structure and properties of the compound make it a promising candidate for the design and development of new therapeutic agents.

Possible biological activity

The compound may exhibit biological activity itself, which could be relevant for the development of new drugs or therapies.

Scaffold for the design of new therapeutic agents

The compound may serve as a structural framework for the development of new drugs, with other functional groups or moieties being added or modified to achieve the desired biological activity.

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 870-63-3 prenyl bromide 
• 503-60-6 3,3-dimethyl-allyl chloride 
• 513-35-9 2-methyl-but-2-ene 
• 556-82-1 3-methyl-2-buten-1-ol 

Downstream Products

• 1423162-31-5 N-[(3-methylbut-2-en-1-yl)oxy]-4-toluenesulfonamide 
• 1423162-41-7 4-bromo-3,3-dimethyl-2-(4-toluenesulfonyl)isoxazolidine 
• 107-86-8 3,3-dimethyl acrylaldehyde 

Relevant academic research and scientific papers

Gassman's cationic [2 + 2] cycloadditions using temporary tethers

An intermolecular equivalent of Gassman's cationic [2 + 2] cycloaddition through the use of temporary tethering is described. Notably, hydrazine and hydroxyamide proved to be robust under the acidic conditions required for the cycloaddition, leading to unique cyclobutane manifolds in a highly regio- and stereoselective manner. This development represents a rare usage of hydrazine and hydroxyamide in the capacity as temporary tethers.

Synthesis and in vitro antiproliferative activity of flavone and 6-hydroxyflavone oxime ethers derivatives

Herein we report the synthesis of a series of O-alkyl oximes of flavone and 6-hydroxyflavone using a simple experimental protocol under solvent free conditions with yields up to 87percent. Cytotoxicity of all compounds was evaluated against MDA-MB-231, PC

Chromatography-free product separation in the Mitsunobu reaction

Mitsunobu products can be isolated pure without column chromatography by first washing a solution of the crude reaction mixture in dichloromethane with 15% aqueous hydrogen peroxide followed by aqueous sodium sulfite. A final filtration through silica gel secures the pure Mitsunobu product.

Novel Mesoionic Insecticidal Compound

The purpose of the present invention is to provide a mesoionic compound, which exhibits an improved controlling effect on various harmful organisms, or a salt thereof. A mesoionic compound represented by formula (1) (wherein: R1 is selected from a hydrogen atom, etc.; R2 represents an optionally substituted phenyl group; R3 is selected from a hydrogen atom, etc.; R4 is selected from a hydrogen atom, etc.; R5 is selected from an optionally substituted ethylene group, etc.; and X is selected from an oxygen atom, etc.) or a salt thereof.

METHOD OF TREATING CANCER WITH A COMBINATION OF BENZYLIDENEGUANIDINE DERIVATIVES AND CHEMOTHERAPEUTIC AGENT.

The present invention relates to a composition for use in treating a glioma or ameliorating the effects of a glioma, particularly glioblastoma, wherein said composition comprises a first active agent selected from the group consisting of a compound of for

O-ALKYL-BENZYLIDENEGUANIDINE DERIVATIVES AND THERAPEUTIC USE FOR THE TREATMENT OF DISORDERS ASSOCIATED AN ACCUMULATION OF MISFOLDED PROTEINS

The present invention relates to a compound of formula (I), or a tautomer and/or a pharmaceutically acceptable salt thereof Formula (I), and its uses to treat a disorder associated with protein misfolding stress and in particular with an accumulation of m

Organocatalytic Radical Involved Oxidative Cross-Coupling of N-Hydroxyphthalimide with Benzylic and Allylic Hydrocarbons

The cross-coupling reaction between N-hydroxyphthalimide and various benzylic and allylic hydrocarbons was realized through an organocatalytic radical-mediated process involving C(sp3)-O bond formation using tert-butyl hydroperoxide (t-BuOOH) as an oxidant and tetra-n-butylammonium iodide [(n-Bu]4NI] as a catalyst, during which the phthalimide N-oxyl (PINO) radical and benzylic and allylic radicals were generated in situ and underwent the selective radical/radical cross-coupling reaction. This novel method provides a convenient metal-free approach to the synthesis of O-alkylated hydroxy imides under mild reaction conditions.

NOVEL VASCULAR LEAKAGEAGE INHIBITOR

The present disclosure relates to a novel vascular leakage inhibitor. The novel vascular leakage inhibitor of the present invention inhibits the apoptosis of vascular endothelial cells, inhibits the formation of actin stress fibers induced by VEGF, and enhances the cortical actin ring structure, thereby inhibiting vascular leakage. Accordingly, the vascular leakage inhibitor of the present invention can prevent or treat various diseases caused by vascular leakage. Since the vascular leakage inhibitor of the present invention is synthesized from commercially available or easily synthesizable pregnenolones, it has remarkably superior feasibility of commercial synthesis.

Diastereoselective bromocyclization of O-allyl-N-tosyl-hydroxylamines

The intramolecular bromoamination of O-allyl-N-tosyl-hydroxylamines results in the formation of isoxazolidines via selective 5-endo-tet cyclization. This process occurs trans-selectively in high yield and diastereoselectivity. The obtained bromo-isoxazoli

Photoinduced electron-transfer-promoted redox fragmentation of N-alkoxyphthalimides

A new photoinduced electron-transfer-promoted redox fragmentation of N-alkoxyphthalimides has been developed. Mechanistic experiments have established that this reaction proceeds through a unique concerted intramolecular fragmentation process. This distinctive mechanism imparts many synthetic advantages, which are highlighted in the redox fragmentation of various heterocyclic substrates.