15715-56-7Relevant academic research and scientific papers
Synthesis of N4-substituted derivatives of 1-[2- (phosphonomethoxy)ethyl]cytosine and its diisopropyl ester as a model reaction for the synthesis of N4-substituted derivatives of cidofovir
Chalupova, Sarka,Holy, Antonin,Masojidkova, Milena
, p. 2066 - 2074 (2007/10/03)
We have studied the reaction of 1-[2-(phosphonomethoxy)ethyl]cytosine (1) and its diisopropyl ester (2) with triethylammonium hydrogensulfite in 60% aqueous methanol. In the presence of some primary or secondary amine salts, at 25-70 °C, this reaction affords transaminated derivatives 4a-4e and 5a, 5b as main products accompanied by uracil compounds. However, with certain amines the reaction failed.
