157188-17-5

Upstream product

• 108-24-7 acetic anhydride 
• 222535-04-8 (E)-3-(ethoxycarbonyl)-4-(4-nitrophenyl)-3-butenic acid 
• 127-09-3 sodium acetate 
• 79290-07-6 ethyl 4-hydroxy-6-nitro-2-naphthalenecarboxylate 
• 555-16-8 4-nitrobenzaldehdye 
• 157188-08-4 tert-butyl (E)-3-(ethoxycarbonyl)-4-(4-nitrophenyl)-3-butenoate 

Downstream Products

• 222535-05-9 4-benzyloxy-6-nitro-naphthalene-2-carboxylic acid ethyl ester 
• 222535-06-0 4-benzyloxy-6-nitro-2-naphthalenecarboxylic acid 
• 222535-07-1 N-(tert-butyloxycarbonyl)-4-benzyloxy-6-nitro-2-naphthylamine 
• 222535-08-2 N-(tert-butyloxycarbonyl)-4-benzyloxy-1-iodo-6-nitro-2-naphthylamine 
• 222835-54-3 N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-4-benzyloxy-1-iodo-6-nitro-2-naphthylamine 
• 286374-28-5 (6-amino-4-benzyloxy-1-iodo-naphthalen-2-yl)-(3-chloro-allyl)-carbamic acid tert-butyl ester 
• 222835-55-4 N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine 
• 222835-56-5 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole 
• 79290-07-6 ethyl 4-hydroxy-6-nitro-2-naphthalenecarboxylate 

Relevant academic research and scientific papers

ASYMMETRIC CONJUGATE COMPOUNDS

The invention relates to compound of formula (I): A-X1-L-X2-B and salts, solvates and tautomers thereof, which are useful as medicaments, in particular as anti-proliferative agents and for use as a drug in an antibody-drug conjugate;

An efficient method for the synthesis of substituted 4-acetoxynaphthalene- 2-carboxylate esters, ethyl 4-acetoxybenzofuran-6-carboxylate, and ethyl 4-acetoxybenzothiophene-6-carboxylate

4-Acetoxynaphthalene-2-carboxylate esters and their corresponding benzofuran and benzothiophene esters are important synthetic intermediates for the preparation of analogs of CC-1065 and the duocarmycins. In this communication, an efficient method for the synthesis of the titled compounds using an Emmons-Horner reaction strategy is reported. As an alternative to the Stobbe condensation reaction, coupling of tert-butyl 3-ethoxycarbonyl-3- (phosphonodiethyl)propionate with a series of aromatic aldehydes, followed by acid promoted removal of the tert-butyl group and Friedel-Crafts reaction, produced the target compounds in good overall yields and of excellent quality.

Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers

Three types of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers were designed, synthesized and evaluated in vitro by NCI against nine types of cancer cells. Biological results showed that the antitumor activities of these seco-CBI dimers were strongly related to the position and length of the linker and generally with potency increasing in the order of C7-C7 dimers (22i-iv)50 values50 values0.01μM against all the cell lines and showed the highest overall potency of the agents examined (GMG=0.0120μM). Copyright (C) 2000 Elsevier Science Ltd.

Substituted naphthoic acids

Certain ureides of substituted naphthoic acids and salts useful as inhibitors of connective tissue destruction.