222835-54-3Relevant academic research and scientific papers
ASYMMETRIC CONJUGATE COMPOUNDS
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Page/Page column 181, (2017/12/01)
The invention relates to compound of formula (I): A-X1-L-X2-B and salts, solvates and tautomers thereof, which are useful as medicaments, in particular as anti-proliferative agents and for use as a drug in an antibody-drug conjugate;
Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers
Jia, Guofeng,Lown, J. William
, p. 1607 - 1617 (2007/10/03)
Three types of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers were designed, synthesized and evaluated in vitro by NCI against nine types of cancer cells. Biological results showed that the antitumor activities of these seco-CBI dimers were strongly related to the position and length of the linker and generally with potency increasing in the order of C7-C7 dimers (22i-iv)50 values50 values0.01μM against all the cell lines and showed the highest overall potency of the agents examined (GMG=0.0120μM). Copyright (C) 2000 Elsevier Science Ltd.
Synthesis of an unsymmetrical bis-lexitropsin-1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) conjugate
Jia, Guofeng,Iida, Hirokazu,Lown, J. William
, p. 119 - 120 (2007/10/03)
A practical synthesis of a novel bis-functionalized precursor of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e] (CBI) is described; the first unsymmetrical bis-lexitropsin-CBI precursor conjugate was thereby synthesized.
