1609205-87-9Relevant academic research and scientific papers
Rh-catalyzed oxidative C2-alkenylation of indoles with alkynes: Unexpected cleavage of directing group
Sharma, Satyasheel,Han, Sangil,Shin, Youngmi,Mishra, Neeraj Kumar,Oh, Hyunji,Park, Jihye,Kwak, Jong Hwan,Shin, Beom Soo,Jung, Young Hoon,Kim, In Su
, p. 3104 - 3107 (2014/05/20)
A rhodium-catalyzed oxidative C2-alkenylation of indoles containing a N-(p-tolyl)carboxamide group with substituted alkynes via C-C bond formation and subsequent C-N bond cleavage has been described. This protocol represents direct access to C-2-alkenylated free (NH)-indoles, which are important building blocks in the synthesis of natural and pharmacological compounds.
