15728-52-6Relevant academic research and scientific papers
Iridium(III)-Catalyzed One-Pot Access to 1,2-Disubstituted Benzimidazoles Starting from Imidamides and Sulfonyl Azides
Xu, Linhua,Wang, Lianhui,Feng, Yadong,Li, Yudong,Yang, Lei,Cui, Xiuling
, p. 4343 - 4346 (2017)
A novel Ir-catalyzed annulation of imidamides with sulfonyl azides has been developed. 1,2-Disubstituted benzimidazoles could be easily obtained in up to 99% yield for more than 40 examples. The products further streamline the synthesis of molecules that are important building blocks for organic synthesis and drug discovery. This strategy features high regioselectivity, efficiency, good tolerance of functional groups, and mild reaction conditions.
Preparation method of 1,2-substituted benzimidazole derivative
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Paragraph 0105; 0106; 0107; 0108, (2017/09/01)
The invention discloses a preparation method of a 1,2-substituted benzimidazole derivative. The preparation method comprises the following steps: uniformly mixing an N-phenyl amidine derivative, a nitrine derivative, an acid compound, a catalyst, a metal salt and an organic solvent; and performing a reaction for 10-13h at 78-82 DEG C in an air atmosphere to obtain the 1,2-substituted benzimidazole derivative. The method disclosed by the invention can be used for synthesizing a compound with a benzimidazole derivative framework, which cannot be synthesized by other methods. The used raw materials are easily available, and the preparation method is high in yield, mild in reaction condition, wide in primer range, small in catalyst dosage, strong in reaction specificity and simple and green in post-treatment, and the utilization ratio of atoms reaches up to 90% and above.
