4547-68-6

Basic information

• Product Name: Benzenesulfonyl azide,4-chloro-
• CAS NO: 4547-68-6
• Molecular Weight: 217.636
• Mol File: 4547-68-6.mol
• Article Data: 39

Chemical Properties

• CAS DataBase Reference: Benzenesulfonyl azide,4-chloro- (CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonyl azide,4-chloro- (4547-68-6)
• EPA Substance Registry System: Benzenesulfonyl azide,4-chloro- (4547-68-6)

Safety Data

• Hazardous Substances Data: 4547-68-6(Hazardous Substances Data)

Upstream product

• 973-63-7 2,4-dinitrophenyl 4-chlorobenzenesulfonate 
• 51-28-5 2,4-Dinitrophenol 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 106-54-7 p-Chlorothiophenol 
• 98-64-6 4-Chlorobenzenesulfonamide 
• 2751-25-9 p-chlorophenylsulfonyl hydrazide 
• 98-66-8 4-chloro-benzenesulfonic acid 

Downstream Products

• 55000-35-6 1-(4-chloro-benzenesulfonylamino)-pyridinium betaine 
• 56799-95-2 N-(1-naphthyl)-4-chlorobenzenesulfonamide 
• 7454-47-9 4-chloro-N-phenyl-benzenesulfonamide 
• 56539-06-1 N?(2?aminophenyl)?4?chlorobenzenesulfonamide 
• 7454-46-8 N-(2-methylphenyl)-4-chlorobenzene sulfonamide 
• 93719-49-4 4-[N-(4-chloro-benzenesulfonyl)-isobutyrimidoyl]-morpholine 
• 94932-10-2 4-[N-(4-chloro-benzenesulfonyl)-cyclohexanecarboximidoyl]-morpholine 
• 75142-76-6 2-p-chlorophenylsulphonylimino-1,1'-dimethylindoline-3-spiro-3'-pyrrolidine 
• 55379-05-0 N-((4-chlorophenyl)sulfonyl)acetamide 
• 75319-69-6 6-(p-chlorophenylsulphonylamino)-2,2a,3,4,5,6-hexahydro-2a,6-methano-1H-azeto<1,2-α><1>benzazocin-12-one 
• 75319-68-5 14-(p-chlorophenyl)-8-(p-chlorophenylsulphonylamino)-13-oxa-14-thia-1,15-diazapentacyclo<10.4.2.0^2,7.0^8,16.0^12,16>octadeca-2,4,6,14-tetraene S oxide 
• 98-64-6 4-Chlorobenzenesulfonamide 
• 101-61-1 4,4'-methylene-bis(N,N-dimethylaniline) 

Relevant articles and documents

Development of prohibitin ligands against osteoporosis

Current therapeutic approaches to osteoporosis display some potential adverse effects and a limited efficacy on non-vertebral fracture reduction. Some sulfonylamidines targeting the scaffold proteins prohibitins-1 and 2 (PHB1/2) have been showed to inhibit the formation of osteoclasts in charge of bone resorption. Herein, we report the development of a second generation of anti-osteoclastic PHB ligands. The most potent compound, IN45, showed 88% inhibition at the low concentration of 5 μM, indicates that it might serve as a basis for the development of new antiosteoporotic drugs.

One-pot synthesis of sulfonyl-1H-1,2,3-triazolyl-thiomorpholine 1,1-dioxide derivatives and evaluation of their biological activity

A one-pot procedure for the synthesis of novel 1,2,3-triazole derivatives (5a–5l) in good yields (63 to 77%) using different sulfonic acids and 4-(prop-2-yn-1-yl)thiomorpholine 1,1-dioxide through the in situ generated sulfonyl azides was developed. The structures of the newly synthesized compounds were confirmed by 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were screened for in?vitro antibacterial activity and free radical scavenging activity in terms of hydrogen donating or radical scavenging ability by the DPPH method. Among all, the compound N-(4-((4-((1,1-dioxidothiomorpholino) methyl)-1H-1,2,3-triazol-1-yl)sulfonyl)phenyl) acetamide (5l) was found to exhibit potent activity as compared to the standard drugs.

Visible-Light-Mediated Sulfonylimination of Tertiary Amines with Sulfonylazides Involving Csp3-Csp3 Bond Cleavage

Visible-light-induced cross-coupling of arylsulfonyl azides with tertiaryamines in the presence of Eosin Y at room temperature has been achieved. This transformation features alkyl C-C bond cleavage and provides a green approach to N-sulfonylamidines under mild conditions.