Bioorganic and Medicinal Chemistry Letters p. 937 - 941 (2007)
Update date:2022-08-04
Topics:
Oon Han, Hee
Hae Kim, Seung
Kim, Kyoung-Hee
Hur, Gwong-Cheung
Joo Yim, Hyeon
Chung, Hee-Kyung
Ho Woo, Sung
Dong Koo, Ki
Lee, Chang-Seok
Sung Koh, Jong
Tae Kim, Geun
Oxime ethers of α-acyl-β-phenylpropanoic acids were prepared to apply as PPARα and γ dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC50 of 19 and 13 nM in PPARα and γ, respectively. It showed better g
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