59276-27-6

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 149-73-5 trimethyl orthoformate 
• 67-56-1 methanol 

Downstream Products

• 123-08-0 4-hydroxy-benzaldehyde 
• 157284-83-8 2-acetyl-3-(4-hydroxy-phenyl)-acrylic acid methyl ester 
• 6935-44-0 ethyl (E)-2-cyano-3-(4-hydroxyphenyl)-2-propenoate 
• 502158-54-5 tris{4-[bis(1,2,4-1H-triazol-1-yl)methyl]phenyl}benzene-1,3,5-tricarboxylate 
• 2538-87-6 trans-p-hydroxycinnamaldehyde 
• 42205-38-9 2-cyano-3-(4-hydroxy-phenyl)-acrylic acid ethyl ester 
• 3785-90-8 2-(4-hydroxyphenylmethylene)malononitrile 

Relevant academic research and scientific papers

Amino acid derivative, feed composition and application thereof

The invention provides an amino acid derivative, a feed composition and application thereof, and belongs to the technical field of animal feed additives. The amino acid derivative is a compound with astructure shown as a formula (I), and a stereoisomer, a tautomer, a solvate, a metabolite, a feed acceptable salt or a prodrug thereof. In formula (I) shown in the specification, Z is a C1-C3 alkylene group. X is an indole ring group with a structure shown as a formula (II). The formula (II) is shown in the specification, wherein Y is phenyl with the structure shown in the formula (III) shown inthe specification. The amino acid derivative is used as an animal feed additive, and can promote the growth of animals and improve the feed conversion.

ANTIBODY DRUG CONJUGATES WITH CLEAVABLE LINKERS

The present invention relates to prodrugs comprising a linker comprising five- or six-membered cyclic acetals and an adjacent specific cleavage site, and to precursor compounds for the synthesis of said prodrugs. In one aspect the present invention relate

Phosphorylated Polyacrylonitrile Fibers as an Efficient and Greener Acetalization Catalyst

A novel solid acid catalyst (PANEAPF) is developed by immobilization of phosphoric acid on polyacrylonitrile fiber through covalent bonding. Various characterization techniques such as elemental analysis (EA), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), etc. are utilized to confirm the successful grafting and the stability of the fiber catalysts during application. PANEAPF shows high catalytic activity in the acetalization of aldehydes owing to the high utilization efficiency of its functionalized acid sites. In addition, the strong polarity micro-environment in the surface layers of PANEAPF make it highly suitable for catalytic application in both water and alcohol. Furthermore, the fiber catalyst can be applied to the acetalization of aldehydes in a continuous-flow process at room temperature, and shows excellent reactivity and superior recyclability (over 20 times). The many advantages of PANEAPF such as simple preparation, convenient regulation of acid amount, high durability, and eco-friendly process make it very attractive for fixed-bed reactors in the chemical industry.

Mesoporous sulfated zirconia mediated acetalization reactions

A novel, convenient, one step synthetic procedure for the synthesis of mesoporous sulfated zirconia (m-SZ) using zirconium carbonate complex and its use as solid acid catalyst for the acetalization of different carbonyl compound is reported. The high specific BET surface area (234 m2 g -1) of m-SZ is achieved after the removal of the surfactant (cetyltrymethylammonium bromide, CTAB) through calcination at 550 °C for 6 h. Microscopic analysis indicated the presence of spherical particles with worm like pores. DRIFT (diffuse reflectance FTIR) of pyridine adsorbed m-SZ and NH3-TPD (temperature programmed desorption) analysis suggested the presence of appreciable amount of Bro?nsted acid sites. The synthesized m-SZ showed high catalytic activity towards protection of carbonyl compounds through acetal/ketal formation. For the open ketal (from cyclohexanone and methanol) 97% conversion with 100% selectivity was obtained in 1 h at room temperature under solvent free condition. The catalyst can be easily recycled after separation from the reaction system without considerable loss in catalytic activity.

An efficient and versatile procedure for the synthesis of acetals from aldehydes and ketones catalyzed by lithium tetrafluoroborate

Acetals are obtained in good to excellent yields by treatment of aldehydes and ketones with trialkyl orthoformate and the corresponding alcohol in the presence of a catalytic amount of lithium tetrafluoroborate. Due to the mild reaction conditions, this method is compatible with acid-sensitive substrates.

An efficient protection of carbonyls and deprotection of acetals using decaborane

Carbonyls were efficiently converted to the corresponding dimethyl acetals at room temperature using trimethyl orthoformate and 1 mol% of decaborane under a nitrogen atmosphere. In turn, acetals were deprotected to the corresponding carbonyls using 1 mol% of decaborane in aqueous THF chemoselectively.

Tetrabutylammonium tribromide (TBATB) as an efficient generator of HBr for an efficient chemoselective reagent for acetalization of carbonyl compounds

Acyclic and cyclic acetals of various carbonyl compounds were obtained in excellent yields under a mild reaction condition in the presence of trialkyl orthoformate and a catalytic amount of tetrabutylammonium tribromide (TBATB) in absolute alcohol. Chemoselective acetalization of an aldehyde in the presence of ketone, unsymmetrical acetal formation, shorter reaction times, mild reaction conditions, the stability of acid-sensitive protecting groups, high efficiencies, facile isolation of the desired products, and the catalytic nature of the reagent make the present methodology a practical alternative.

Microwave assisted selective cleavage of sulfonates and sulfonamides in dry media

A simple and efficient method for the cleavage of Sulfonates and Sulfonamides has been achieved for the first time under microwave irradiation conditions using KF-Al2O3.

Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues

Eighteen analogues of the nonintercalative DNA topoisomerase II (topo II)-active epipodophyllotoxin-ellipticine hybrid, azatoxin, were synthesized and evaluated for their ability to induce topo II-mediated DNA strand breaks in vitro. In general, the SAR p

Tetralin esters of phenols or benzoic acids having retinoid like activity

Retinoid-like activity is exhibited by compounds of the formula STR1 where the R groups are independently hydrogen, or lower alkyl; A is --C(O)O--, --OC(O)--, --C(O)S--, or --SC(O)--; n is 0-5; and Z is H, --COB where B is --OH or a pharmaceutically acceptable salt, or B is --OR 1 where R 1 is an ester-forming group, or B is --N(R) 2 where R is hydrogen or lower alkyl, or Z is --OE where E is hydrogen or an ether-forming group or --COR 2 where R 2 is hydrogen, lower alkyl, phenyl or lower alkyl phenyl, or Z is --CHO or an acetal derivative thereof, or Z is --COR 3 where R 3 is --(CH 2) m CH 3 where m is 0-4 and the sum of n and m does not exceed 4.